2. 重组蛋白
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Immunoglobulin-like Cell Adhesion Molecules
  6. IGSF1 蛋白, Human (Cell-Free, His)

IGSF1 蛋白, Human (Cell-Free, His)

目录号: HY-P702334
产品使用指南

IGSF1 蛋白在抑制素信号传导中充当辅助受体，无论是否存在抑制素 B，都能够严重拮抗激活素 A 信号传导。它在抑制素 B 对激活素刺激的转录的特异性拮抗作用中发挥关键作用，并与 INHA 相互作用。IGSF1 蛋白, Human (Cell-Free, His) 是重组的 IGSF1 蛋白，由 E. coli Cell-free 表达，带有 N-10*His 标签。IGSF1 蛋白, Human (Cell-Free, His) 全长 1336 个氨基酸，分子量为 151.8 kDa。

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描述

The IGSF1 protein acts as a coreceptor in inhibin signaling and is able to critically antagonize activin A signaling regardless of the presence of inhibin B. It plays a key role in the specific antagonism of inhibin B to activin-stimulated transcription and interacts with INHA. IGSF1 Protein, Human (Cell-Free, His) is the recombinant human-derived IGSF1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of IGSF1 Protein, Human (Cell-Free, His) is 1336 a.a., with molecular weight of 151.8 kDa.
研究背景

IGSF1 蛋白在抑制素信号传导中充当辅助受体，尽管它似乎不具有高亲和力抑制素受体的功能。无论抑制素 B 是否存在，它在拮抗激活素 A 信号传导中都发挥着至关重要的作用。该蛋白对于介导抑制素 B 对激活素刺激的转录的特定拮抗作用至关重要，并且它与 INHA 相互作用。虽然标准受体结合测定表明在一项研究中与 INHA 没有相互作用，但已知 IGSF1 与 ACVR1B 相互作用，并且这种相互作用似乎是配体依赖性的，被抑制素 B 和激活素 A 减弱。此外，IGSF1 与 ACVR2A、ACVR2B 相互作用、ACVRL1、BMPR1B 和 HECTD1，揭示了其参与复杂的蛋白质相互作用网络，对于调节抑制素和激活素信号通路至关重要。
种属

Human
表达系统

E. coli Cell-free
标签

N-10*His
蛋白编号

Q8N6C5 (M1-I1336)
基因 ID

3547
蛋白结构
N-term
10*His
IGSF1 (M1-I1336)
Accession # Q8N6C5
C-term
同用名
Immunoglobulin superfamily member 1; Immunoglobulin-like domain-containing protein 1; Inhibin-binding protein; InhBP; Pituitary gland-specific factor 2; p120
氨基酸序列

MTLDRPGEGATMLKTFTVLLFCIRMSLGMTSIVMDPQPELWIESNYPQAPWENITLWCRSPSRISSKFLLLKDKTQMTWIRPSHKTFQVSFLIGALTESNAGLYRCCYWKETGWSKPSKVLELEAPGQLPKPIFWIQAETPALPGCNVNILCHGWLQDLVFMLFKEGYAEPVDYQVPTGTMAIFSIDNLTPEDEGVYICRTHIQMLPTLWSEPSNPLKLVVAGLYPKPTLTAHPGPIMAPGESLNLRCQGPIYGMTFALMRVEDLEKSFYHKKTIKNEANFFFQSLKIQDTGHYLCFYYDASYRGSLLSDVLKIWVTDTFPKTWLLARPSAVVQMGQNVSLRCRGPVDGVGLALYKKGEDKPLQFLDATSIDDNTSFFLNNVTYSDTGIYSCHYLLTWKTSIRMPSHNTVELMVVDKPPKPSLSAWPSTVFKLGKAITLQCRVSHPVLEFSLEWEERETFQKFSVNGDFIISNVDGKGTGTYSCSYRVETHPNIWSHRSEPLKLMGPAGYLTWNYVLNEAIRLSLIMQLVALLLVVLWIRWKCRRLRIREAWLLGTAQGVTMLFIVTALLCCGLCNGVLIEETEIVMPTPKPELWAETNFPLAPWKNLTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQVRAAFPLGALTQSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASPTIRGQELQLRCKGWLAGMGFALYKEGEQEPVQQLGAVGREAFFTIQRMEDKDEGNYSCRTHTEKRPFKWSEPSEPLELVIKEMYPKPFFKTWASPVVTPGARVTFNCSTPHQHMSFILYKDGSEIASSDRSWASPGASAAHFLIISVGIGDGGNYSCRYYDFSIWSEPSDPVELVVTEFYPKPTLLAQPGPVVFPGKSVILRCQGTFQGMRFALLQEGAHVPLQFRSVSGNSADFLLHTVGAEDSGNYSCIYYETTMSNRGSYLSMPLMIWVTDTFPKPWLFAEPSSVVPMGQNVTLWCRGPVHGVGYILHKEGEATSMQLWGSTSNDGAFPITNISGTSMGRYSCCYHPDWTSSIKIQPSNTLELLVTGLLPKPSLLAQPGPMVAPGENMTLQCQGELPDSTFVLLKEGAQEPLEQQRPSGYRADFWMPAVRGEDSGIYSCVYYLDSTPFAASNHSDSLEIWVTDKPPKPSLSAWPSTMFKLGKDITLQCRGPLPGVEFVLEHDGEEAPQQFSEDGDFVINNVEGKGIGNYSCSYRLQAYPDIWSEPSDPLELVGAAGPVAQECTVGNIVRSSLIVVVVVALGVVLAIEWKKWPRLRTRGSETDGRDQTIALEECNQEGEPGTPANSPSSTSQRISVELPVPI

分子量

151.8 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

IGSF1 Protein, Human (Cell-Free, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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