IL-19 蛋白, Human

IL-19 Protein, Human is a member of the Interleukin-10 family. The biological functions and clinical implications of Interleukin-19 is still undefined.

IL-19 与 IL-10 具有 21% 的氨基酸同一性。IL-19的外显子/内含子结构与人IL-10基因的外显子/内含子结构相似，在IL-19 cDNA的编码区内包含五个外显子和四个内含子。IL-19 不结合经典 IL-10 受体复合物或通过其发出信号^[1]。IL-19 通过由 IL-20Ra 和 IL20Rb 组成的受体复合物发挥作用，IL-20 和 IL-24 也利用该受体复合物。IL19 已被证明可以增强 T 细胞中 Th2 细胞因子的产生，并且在哮喘患者中升高。此外，它还诱导单核细胞中 IL-6、IL-8 和 IL-10 的表达。此外，它还与一系列疾病和紊乱有关，包括衰老、I 型糖尿病、内毒素性休克、牙周病、血管疾病和类风湿性关节炎^[2]。

The ED₅₀ is <1.5 ng/mL as measured by murine BaF3 pro-B cells, corresponding to a specific activity of >6.7 × 10⁵ units/mg.

Human

E. coli

Tag Free

Q9UHD0-1 (L25-A177)

29949  [NCBI]

LRRCLISTDMHHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMSSA

Approximately 17.9 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Gallagher G, et al. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Genes Immun. 2000 Oct;1(7):442-50.  [Content Brief]

  [2]. Gallagher G, et al. Interleukin-19: multiple roles in immune regulation and disease. Cytokine Growth Factor Rev. 2010 Oct;21(5):345-52.  [Content Brief]