IL19 - interleukin 19 Gene

中文名称：白细胞介素 19

种属: Homo sapiens

同用名: MDA1; NG.1; ZMDA1; IL-10C

基因 ID: 29949 | 基因类型: protein coding

关于 IL19

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,770,773-206,842,981 (from NCBI)

This gene has 6 transcripts (splice variants), 185 orthologues and 4 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是一种属于 IL10 细胞因子亚家族的细胞因子。发现该细胞因子优先在单核细胞中表达。它可以结合 IL20 受体复合物并导致信号转导和转录激活因子 3 (STAT3) 的激活。据报道，小鼠中的一种类似细胞因子可上调 IL6 和 TNF-α 的表达并诱导细胞凋亡，这表明该细胞因子在炎症反应中的作用。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce Apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

IL19 基因产物(5)

mRNA	Protein	Name
NM_001369605.1	NP_001356534.1	interleukin-19 precursor
NM_001393490.1	NP_001380419.1	interleukin-19 precursor
NM_001393491.1	NP_001380420.1	interleukin-19 precursor
NM_013371.5	NP_037503.2	interleukin-19 precursor
NM_153758.5	NP_715639.2	interleukin-19 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	22802649	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL19 蛋白结构

IL10

0
100
177 a.a.

蛋白主名

其他名称

interleukin-19

melanoma differentiation associated protein-like protein

重组 IL19 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7212	IL-19 Protein, Human	Q9UHD0-1 (L25-A177)	≥95%
HY-P73183	IL-19 Protein, Human (sf9, His)	Q9UHD0-1 (L25-A177)	≥95%
HY-P73184	IL-19 Protein, Human (HEK293, His)	Q9UHD0-1 (L25-A177)	≥95%
HY-P700109AF	Animal-Free IL-19 Protein, Human (His)	AAK91776.1 (L63-A215)	≥95%

关联疾病

疾病名称

别名

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Psoriasis

Fungal Esophagitis

Psoriasis 12

PSORS12	Psoriasis Susceptibility 12
Psoriasis 12, Susceptibility To

Pustulosis Of Palm And Sole

Psoriasis	Acropustulosis
Palmoplantar Pustulosis	Pustular Psoriasis Of The Palms And/Or Soles
Pustulosis Of Palms And Soles	Acrodermatitis Continua Of Hallopeau
Generalized Pustular Psoriasis

Chronic Recurrent Multifocal Osteomyelitis

Chronic Multifocal Osteomyelitis	CRMO
Cmo	Cno/Crmo
Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis	Osteomyelitis, Chronic Multifocal
Multifocal Osteomyelitis, Chronic	Chronic Osteomyelitis
Chronic Multifocal Osteomyelitis, Unspecified Site	Crmo - [Chronic Multifocal Osteomyelitis]
Chronic Osteomyelitis With Draining Sinus, Unspecified Site	Bone Fistula With Chronic Osteomyelitis

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Psoriasis 14, Pustular

Generalized Pustular Psoriasis	Gpp
Ditra	Acrodermatitis Continua Of Hallopeau
Palmoplantar Pustulosis	PSORS14
Interleukin 36 Receptor Antagonist Deficiency	Psorp
Pustular Psoriasis 14	Deficiency Of Il-36r Antagonist
Acute Generalised Pustular Psoriasis	Deficiency Of The Interleukin-36 Receptor Antagonist
Generalized Pustular Psoriasis Of Von Zumbusch	Von Zumbusch Psoriasis
Deficiency Of Il-36ra	Psoriasis, Pustular, Generalized
Psoriasis, Pustular, Type 14	Pustulosis Of Palms And Soles
Acute Generalized Pustular Psoriasis	Palmoplantar Pustular Psoriasis
Pustulosis Palmaris Et Plantaris	Ppp - [Palmoplantar Pustulosis]
Pustular Psoriasis Of The Palms And Soles	Pustular Bacterid

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Autoimmune Disease Of Skin And Connective Tissue

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06712	IL19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	IL19	VGNC	VGNC:107882
Bos taurus	IL19	VGNC	VGNC:30129
Canis familiaris	IL19	VGNC	VGNC:41955
Macaca mulatta	IL19	VGNC	VGNC:99979
Mus musculus	IL19	MGD	MGI:1890472
Rattus norvegicus	IL19	RGD	RGD:1583546
Others	IL19	NCBI

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