IL-22BP/IL-22RA2 蛋白, Human (HEK293, His)

IL-22BP/IL-22RA2 proteins (especially isoform 2) act as IL22 receptors and antagonists, inhibiting IL22 activity by preventing its interaction with functional IL-22R complexes in vitro. This regulatory effect suggests its potential in modulating inflammatory responses. IL-22BP/IL-22RA2 Protein, Human (HEK293, His) is the recombinant human-derived IL-22BP/IL-22RA2 protein, expressed by HEK293 , with C-6*His labeled tag.

IL-22BP，特别是异构体 2，充当 IL22 的受体。该亚型不仅与 IL22 结合，而且还通过阻止 IL22 与功能性 IL-22R 复合物之间的相互作用充当拮抗剂，从而在体外抑制 IL22 的活性。同工型 2 的调节功能表明其可能参与调节炎症反应。另一方面，异构体 1 涉及与建立和维持成功妊娠相关的过程，表明在生殖生理学中具有独特的作用。IL-22BP 亚型的双重作用凸显了它们在影响炎症途径和生殖结果方面的多功能性。

Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells. The ED₅₀ for this effect is 1.736 ng/mL in the presence of 1 ng/mL of Human IL-22, corresponding to a specific activity is 5.76×10⁵ U/mg.

Human

HEK293

C-6*His

Q969J5-2 (T22-P231)

116379  [NCBI]

TQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVYFVQYKIYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWETKIDPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIEDYYELLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSSYCVVAEIYQPMLDRRSQRSEERCVEIP

Approximately 40-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.