IL-23R 蛋白, Canine (HEK293, His)

IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Canine (HEK293, His) is the recombinant canine-derived IL-23R protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-23R Protein, Canine (HEK293, His) is 331 a.a., with molecular weight of 55-70 kDa.

IL-23R 蛋白与 IL12RB1 结合形成白细胞介素 23 受体。作为 IL23 的结合位点，该受体可能通过 Jak-Stat 信号级联的激活介导 T 细胞、NK 细胞以及可能某些巨噬细胞/骨髓细胞的刺激。IL-23R 在先天性和适应性免疫中发挥着至关重要的作用，可能有助于外周组织对感染的急性反应。此外，IL-23R 与自身免疫性炎症性疾病有关，并且被认为在肿瘤发生中具有重要意义。IL-23R 复合物与 IL12RB1 形成异二聚体，当暴露于 IL23 时，形成功能性 IL23 受体。此外，IL-23R 与 JAK2 相互作用，并且在 IL23 存在的情况下与 STAT3 结合，促进下游信号传导过程（通过相似性）。

Immobilized Canine IL-23R, His Tag at 5 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC₅₀ of ≤3 μg/mL determined by ELISA.

Canine

HEK293

C-His

A0A8I3PXL0 (G24-D354)

609732  [NCBI]

55-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.