IL-23R 蛋白, Rat (HEK293, Fc)

IL-23R Protein, critical in immune response, forms the interleukin-23 receptor by associating with IL12RB1. Binding to IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. Associated with autoimmune diseases and tumorigenesis, IL-23R, in the presence of IL12RB1, forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. IL-23R Protein, Rat (HEK293, Fc) is the recombinant rat-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-23R Protein, Rat (HEK293, Fc) is 367 a.a., with molecular weight of ~69.4 kDa.

白细胞介素 23 受体 (IL-23R) 在免疫反应中发挥着关键作用，因为它通过与 IL12RB1 结合形成白细胞介素 23 受体。它与 IL23 结合，并通过 Jak-Stat 信号级联触发 T 细胞、NK 细胞以及潜在的某些巨噬细胞/骨髓细胞的激活。IL23 参与先天性免疫和适应性免疫，并且可能有助于外周组织对感染的急性反应。此外，IL23 与自身免疫性炎症性疾病有关，并已被证明在肿瘤发生中发挥重要作用。当 IL12RB1 存在时，IL-23R 形成异二聚体，充当 IL-23 受体。它与 JAK2 相互作用，并且在 IL23 存在的情况下激活 STAT3。IL23/IL-23R 促进 T 辅助细胞 1 和 T 辅助细胞 17 的分化和促炎细胞因子的分泌，从而增加宿主的杀菌活性^[1][2][3]。

Measured by its ability to bind recombinant Human IL-23 in a functional ELISA.

Rat

HEK293

C-hFc

XP_003753958.1 (M1-D367)

689932  [NCBI]

Approximately 69.4 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.