IL-2R alpha/CD25 蛋白, Human (HEK293, His-Avi)

IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions^[1][2]. IL-2R alpha/CD25 Protein, Human (HEK293, His-Avi) is a recombinant human IL-2R alpha protein with a His tag and an Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 192 amino acids (E22-C213).

IL-2R α (CD25) 是一种 I 型膜蛋白。IL-2R α 在外周激活的 T 细胞和 B 细胞、三阴性胸腺细胞和骨髓前 B 细胞中表达。在高肿瘤调节性 T (Treg) 细胞中，IL-2R α 高表达，是 Treg 缺失的潜在靶点。在静息 T 细胞上检测不到 IL-2R α 的表达^[1][2][3]。
序列不同物种的IL-2Rα的氨基酸差异很大（人、大鼠和小鼠之间的相似性低于85%）。
IL-2Rα是高亲和力IL-2受体的重要组成部分，本身不具有信号转导活性。IL-2R α 通过增强 IL-2 与其受体复合物的结合发挥作用，并充当正反馈调节剂。IL-2是T淋巴细胞的主要生长因子，在T细胞免疫反应中发挥重要作用。IL-2R α 转录受三个正调节区 (PRR) 调节：PRRI、PRRII 和 PRRIII。PRRIII 是一种 IL-2 反应元件^[1][2]。
IL-2R α 调节 T 细胞生长，增强淋巴细胞活化和增殖。IL-2R α 参与预防 1 型糖尿病和癌症^[1][2][4]。

Human

HEK293

C-Avi;C-His

P01589 (E22-C213)

3559  [NCBI]

40-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.

• [1]. H.Asao. Interleukin-2. Reference Module in Biomedical Sciences. 2014. ISBN 9780128012383.

  [2]. Kim HP, et al. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity. 2001 Jul;15(1):159-72.  [Content Brief]

  [3]. Bell CJ, et al. Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells. J Autoimmun. 2015 Jan;56:66-80.  [Content Brief]

  [4]. Chistiakov DA, et al. The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett. 2008 Jun 15;118(1):1-5.  [Content Brief]