IL-31 蛋白, Human

IL-31 Protein, Human is a novel T-helper-lymphocyte-derived cytokine that plays an important role in allergic skin inflammation and atopic dermatitis.

白介素 31 (IL-31)，优先由 2 型辅助 T 细胞产生。IL-31 通过由 IL-31 受体 A 和制瘤素 M 受体组成的受体发出信号。IL-31 可能参与促进过敏性和非过敏性疾病特征的皮炎和上皮反应^[1]。特应性皮炎、慢性自发性荨麻疹、过敏性接触性皮炎、结节性痒疹、原发性皮肤淋巴瘤和肥大细胞增多症患者的血清 IL-31 蛋白水平升高，皮肤中 IL-31 mRNA 升高^[2]。

The ED₅₀ is <5 ng/mL as measured by human U-87 MG cells.

Human

E. coli

Tag Free

Q6EBC2 (S24-T164)

386653  [NCBI]

SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT

Approximately 15.8 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Dillon SR, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 2004 Jul;5(7):752-60.  [Content Brief]

  [2]. Rabenhorst A, et al. Interleukin-31: a novel diagnostic marker of allergic diseases. Curr Allergy Asthma Rep. 2014 Apr;14(4):423.  [Content Brief]