2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-33
  6. IL-33 蛋白, Cynomolgus (HEK293, His)

IL-33 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P77966
产品使用指南

IL-33 蛋白是 IL-1 家族的一部分，是一种在免疫反应和炎症中至关重要的不同细胞因子。IL-33 通过其受体 ST2 发挥作用，促进 Th2 细胞、肥大细胞和嗜酸性粒细胞等免疫细胞的激活和募集到炎症部位。IL-33 由上皮细胞和内皮细胞产生，可诱导促炎细胞因子和趋化因子。IL-33 与哮喘、过敏性疾病和自身免疫性疾病有关，成为免疫反应调节的治疗靶点。IL-33 蛋白, Cynomolgus (HEK293, His) 是重组的 IL-33 蛋白，由 HEK293 表达，带有 N-His 标签。IL-33 蛋白, Cynomolgus (HEK293, His) 全长 162 个氨基酸，分子量为 25-30 kDa。

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描述

IL-33 Protein, part of the IL-1 family, is a divergent cytokine pivotal in immune responses and inflammation. Operating through its receptor ST2, IL-33 promotes activation and recruitment of immune cells like Th2 cells, mast cells, and eosinophils to inflammation sites. Produced by epithelial and endothelial cells, IL-33 induces pro-inflammatory cytokines and chemokines. Implicated in asthma, allergic diseases, and autoimmune disorders, IL-33 emerges as a therapeutic target for immune response modulation. IL-33 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-33 protein, expressed by HEK293, with N-His labeled tag. The total length of IL-33 Protein, Cynomolgus (HEK293, His) is 162 a.a., with molecular weight of 25-30 kDa.
研究背景

IL-33 蛋白属于 IL-1 家族，因其与其他家族成员的高度差异而闻名。它作为一种重要的细胞因子参与各种免疫反应和炎症过程。IL-33 在促进免疫细胞（例如辅助性 T 2 (Th2) 细胞、肥大细胞和嗜酸性粒细胞）激活和募集到炎症部位方面发挥着至关重要的作用。它主要由上皮细胞和内皮细胞产生，并通过其受体 ST2 发挥作用，诱导其他促炎细胞因子和趋化因子的产生。IL-33 与多种疾病有关，包括哮喘、过敏性疾病和自身免疫性疾病，凸显了其作为调节免疫反应的治疗靶点的重要性。
种属

Cynomolgus
表达系统

HEK293
标签

N-His
蛋白编号

A0A2K5W3I1 (H109-I270)
基因 ID
蛋白结构
N-term
His
IL-33 (H109-I270)
Accession # A0A2K5W3I1
C-term
同用名
C9orf26 Z; DVS27; IL1F11; NF-HEV; NFEHEV; IL33; DV27; C9ORF26; RP11-575C20.2
分子量

25-30 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

IL-33 Protein, Cynomolgus (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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