IL-34 蛋白, Human (CHO, His)

IL-34 protein is an important cytokine that promotes the proliferation, survival, and differentiation of monocytes and macrophages. It plays a key role in innate immune responses and inflammatory processes by promoting the release of pro-inflammatory chemokines. IL-34 Protein, Human (CHO, His) is the recombinant human-derived IL-34 protein, expressed by CHO , with C-His labeled tag.

白介素 34 (IL-34) 是一种细胞因子，在先天免疫和炎症过程中具有关键功能，因为它促进单核细胞和巨噬细胞的增殖、存活和分化。此外，IL-34 在调节破骨细胞增殖和分化、影响骨吸收方面发挥着至关重要的作用。细胞因子的影响是通过其与 CSF1R 的相互作用介导的，导致下游效应器的激活以及随后 MAPK1/ERK2 和 MAPK3/ERK1 的磷酸化。从结构上看，IL-34 以同二聚体形式存在，其在免疫调节和骨稳态中的复杂参与凸显了其在协调细胞反应和维持组织完整性方面的重要性。

Measured in a cell proliferation assay using human peripheral blood mononuclear cell and the ED₅₀ is 2-8 ng/mL.

Human

CHO

C-His

Q6ZMJ4-1/AAH29804.1 (N21-P242)

146433  [NCBI]

NEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVQTLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP

Approximately 26.7 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.