IL34 - interleukin 34 Gene

中文名称：白细胞介素 34

种属: Homo sapiens

同用名: IL-34; C16orf77

基因 ID: 146433 | 基因类型: protein coding

关于 IL34

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,579,899-70,660,682 (from NCBI)

This gene has 5 transcripts (splice variants) and 91 orthologues. Biased expression in spleen (RPKM 59.9), skin (RPKM 16.8) and 5 other tissues.

功能概要

白细胞介素 34 是一种细胞因子，可通过集落刺激因子 1 受体 (CSF1R；MIM 164770) 促进单核细胞和巨噬细胞的分化和活力 (Lin 等人，2008 [PubMed 18467591]) 。[OMIM 提供，5 月 2008]

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

IL34 基因产物(9)

mRNA	Protein	Name
NM_001172771.2	NP_001166242.1	interleukin-34 isoform 2 precursor
NM_001172772.2	NP_001166243.1	interleukin-34 isoform 1 precursor
NM_001393493.1	NP_001380422.1	interleukin-34 isoform 1 precursor
NM_001393494.1	NP_001380423.1	interleukin-34 isoform 1 precursor
NM_001393495.1	NP_001380424.1	interleukin-34 isoform 2 precursor
NM_001393496.1	NP_001380425.1	interleukin-34 isoform 2 precursor
NM_001393497.1	NP_001380426.1	interleukin-34 isoform 3
NM_001393498.1	NP_001380427.1	interleukin-34 isoform 4
NM_152456.3	NP_689669.2	interleukin-34 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	22483114	GOA
enables macrophage colony-stimulating factor receptor binding	IDA IDA: 通过直接分析推断	18467591	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	22483114	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in interleukin-34-mediated signaling pathway	IDA IDA: 通过直接分析推断	26754294	GOA
acts upstream of or within positive regulation of MAP kinase activity	IDA IDA: 通过直接分析推断	26754294	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	18467591	GOA
acts upstream of positive regulation of macrophage chemotaxis	IDA IDA: 通过直接分析推断	26754294	GOA
involved in positive regulation of macrophage differentiation	IDA IDA: 通过直接分析推断	23409120	GOA
acts upstream of positive regulation of macrophage proliferation	IDA IDA: 通过直接分析推断	26754294	GOA
involved in positive regulation of monocyte differentiation	IDA IDA: 通过直接分析推断	23409120	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	18467591	GOA
acts upstream of or within positive regulation of protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	26754294	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	18467591	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL34 蛋白结构

IL34

0
100
200
242 a.a.

蛋白主名

其他名称

interleukin-34

重组 IL34 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73211	IL-34 Protein, Human (CHO, His)	Q6ZMJ4-1/AAH29804.1 (N21-P242)	≥95%
HY-P700125AF	Animal-Free IL-34 Protein, Human (His)	Q6ZMJ4-1 (N21-P242)	≥95%

关联疾病

疾病名称

别名

Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

Hereditary Diffuse Leukoencephalopathy With Spheroids	Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia
Alsp	Gpsc
Subcortical Gliosis Of Neumann	Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1
Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids	Hdls
HDLS1	Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia
Gliosis, Familial Progressive Subcortical	Leukoencephalopathy, Diffuse Hereditary, With Spheroids
Pold	Pigmentary Orthochromatic Leukodystrophy
Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia	Familial Progressive Subcortical Gliosis
Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant	Dementia, Familial, Neumann Type
Adult-Onset Leukodystrophy With Neuroaxonal Spheroids	Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids
Neuroaxonal Leukodystrophy	Fpsg
Familial Dementia, Neumann Type	Familial Dementia Neumann Type
Leukoencephalopathy, Diffuse Hereditary, With Spheroid

Tenosynovial Giant Cell Tumor

Fibrous Histiocytoma Of Tendon Sheath	Giant Cell Tumor Of Tendon Sheath
Giant Cell Tumor Of Tenosynovium	Giant Cell Tumour Of Tendon Sheath
Giant Cell Tumour Of Tenosynovium	Tenosynovial Giant Cell Tumour
Diffuse-Type Gct	Diffuse-Type Giant Cell Tumor
Pigmented Villonodular Synovitis	Tgct
Tsgct

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Pigmented Villonodular Synovitis

Diffuse Giant Cell Tumor Of Tenosynovium	Villous Tenosynovitis
Diffuse Pigmented Villonodular Synovitis	Diffuse-Type Gct
Diffuse-Type Giant Cell Tumor	Localized Pigmented Villonodular Synovitis
Tgct	Tsgct
Tenosynovial Giant Cell Tumor	Tenosynovial Giant Cell Tumors
Synovitis Pigmented Villonodular	Synovitis, Pigmented Villonodular
Fibrous Histiocytoma Of Tendon Sheath	Testicular Germ Cell Tumor
Chronic Haemorrhagic Villous Synovitis	Pvns - [Pigmented Villonodular Synovitis]
Villonodular Synovitis

Gallbladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Gallbladder

Epidermoid Gallbladder Carcinoma

Peripheral Nerve Schwannoma

Chronic Apical Periodontitis

Apical Periodontitis Nos	Apex Periodontitis
Periapical Infection Nos

Bone Benign Neoplasm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06758	IL34 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IL34	MGD	MGI:1923777
Macaca mulatta	IL34	VGNC	VGNC:73669
Rattus norvegicus	IL34	RGD	RGD:1586038
Bos taurus	IL34	VGNC	VGNC:30156
Canis familiaris	IL34	VGNC	VGNC:41983
Felis catus	IL34	VGNC	VGNC:62913
Others	IL34	NCBI

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