IL-4 蛋白, Porcine (CHO)

IL-4 Protein, Porcine (CHO) is the prime anti-infalmmatory cytokine involves in cell proliferation, various gene expression and avert apoptosis in IL-4 expressing cells.

IL-4 信号传导的作用是通过 IL-4 受体 α 链 (IL-4Rα) 介导的。与其配体结合后，IL-4Rα 与常见的 γ 链 (γc) 形成二聚体，产生主要位于造血细胞上的 1 型信号复合物，或与 IL-13 受体 α 1 (IL-13Rα1) 形成二聚体，产生2 型复合物，也在非造血细胞上表达^[1]。

The ED₅₀ is <0.25 ng/mL as measured by TF-1 human erythroleukemic cells, corresponding to a specific activity of >4.0 × 10⁶ units/mg.

Porcine

CHO

Tag Free

Q04745 (H25-C133)

397225  [NCBI]

HKCDITLQEIIKTLNILTARKNSCMELPVTDVFAAPENTTEKETFCRASTVLRHIYRHHTCMKSLLSGLDRNLSSMANMTCSVHEAKKSTLKDFLERLKTIMKEKYSKC

Approximately 15 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Gadani SP, et al. IL-4 in the brain: a cytokine to remember. J Immunol. 2012 Nov 1;189(9):4213-9.  [Content Brief]