IL-5R alpha 蛋白, Human (HEK293, His)

IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (HEK293, His) is expressed by HEK293 cells with a C-6*His tag^[1][3].

IL-5R α 是一种 I 型细胞因子受体，由两条不同的多肽链 α 和 β 组成。α 链是一种穿膜糖蛋白，可特异性结合 IL-5，β 链可将低亲和力 IL-5R 转化为高亲和力 IL-5R，形成异二聚体受体复合物^[1]。
IL-5R α 与 IL-5 结合后可诱导多种细胞内信号通路的激活，包括 JAK/STAT、RAF/MAP、Ras-Raf-ERK 和磷脂酰肌醇 3-激酶^[2] .
IL-5R α 在嗜酸性粒细胞、嗜碱性粒细胞和 B 细胞上表达，影响细胞存活、凋亡、分化和趋化性^[3]。

Human

HEK293

C-6*His

Q01344-1 (D21-E335)

3568  [NCBI]

DLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDE

45-60 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. S Takaki, et al. A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction. Mol Cell Biol. 1994 Nov;14(11):7404-16.  [Content Brief]

  [2]. R P de Groot, et al. Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. Cell Signal. 1998 Oct;10(9):619-31.  [Content Brief]

  [3]. S C Barry, et al. Analysis of interleukin 5 receptors on murine eosinophils: a comparison with receptors on B13 cells. Cytokine. 1991 Jul;3(4):339-47.  [Content Brief]