IL-7 蛋白, Mouse (CHO)

IL-7 Protein, Mouse (CHO) is constitutively produced by stromal cells from the bone marrow and thymus, plays a crucial role in B cell lymphopoiesis and in T cell homeostasis.

白介素 7 (IL-7) 是一种由非淋巴细胞产生的非冗余细胞因子，对于人类和小鼠 T 细胞发育以及小鼠 B 细胞发育至关重要。IL-7 通过 IL-7 受体提供生长和生存信号，有助于维持外周 T 细胞库的大小和子集组成。IL-7 受体具有私有 α 链，并与其他常见细胞因子受体使用者（例如 IL-2、IL-4、IL-15、和IL-21。IL-7 与这些细胞因子一起调节适应性免疫反应的扩展和收缩，并可能调节对给定抗原的记忆反应。IL-7 调节记忆 CD8⁺ T 细胞以应对病毒感染，并与 1 型单纯疱疹病毒感染后 T 细胞的过继转移结合使用，可提高病毒清除率^[1] 。

The ED₅₀ is <0.4 ng/mL as measured by 2E8 cells.

Mouse

CHO

C-His

P10168/Q544C8/NP_032397.1 (E26-I154)

16196  [NCBI]

ECHIKDKEGKAYESVLMISIDELDKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVHLLTVSQGTQTLVNCTSKEEKNVKEQKKNDACFLKRLLREIKTCWNKILKGSIHHHHHH

8-28 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Moniuszko M, et al. Recombinant interleukin-7 induces proliferation of naive macaque CD4⁺ and CD8⁺ T cells in vivo. J Virol. 2004 Sep;78(18):9740-9.  [Content Brief]