Integrin alpha 2 beta 1 蛋白, Human (HEK293, His)

ITGA2 Protein, a transmembrane receptor, is involved in cell adhesion, platelet aggregation, and tumor metastasis. Dysregulation of ITGA2 Protein has been associated with various disorders, including thrombosis and cancer. Targeting ITGA2 Protein may offer potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting blood clot formation, and preventing tumor metastasis. Integrin alpha 2 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2 beta 1 Protein, Human (HEK293, His), has molecular weight of 110-140 kDa.

整合素 α-2/β-1，也称为 ITGA2 蛋白，作为各种细胞外基质分子（例如层粘连蛋白、胶原蛋白、胶原 C 前肽、纤连蛋白和 E-钙粘蛋白）的受体。具体来说，它识别胶原蛋白中的脯氨酸羟基化序列 GFPGER。这种整合素负责介导血小板和其他细胞与胶原蛋白的粘附，以及调节胶原蛋白和胶原酶基因的表达，产生机械力，并组织新合成的细胞外基质。此外，在微生物感染的情况下，ITGA2:ITGB1 复合物充当人类轮状病毒 A 的受体。

Human

HEK293

C-His

P17301-1 (Y30-T1132)&P05556 (Q21-D728)

3673&3688

110-140 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.