2. 重组蛋白
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Integrin
  6. Integrin alpha 1 beta 1
  7. Integrin alpha A1 beta 1 蛋白, Human (HEK293, His)

Integrin alpha A1 beta 1 蛋白, Human (HEK293, His)

目录号: HY-P700756
产品使用指南 技术支持

ITGA1 蛋白是一种细胞表面受体，在细胞粘附、迁移和组织发育中发挥着至关重要的作用。ITGA1 蛋白的失调与多种疾病有关，包括癌症和纤维化。靶向 ITGA1 蛋白可能通过调节细胞粘附、抑制肿瘤生长和防止组织纤维化为这些病症提供潜在的治疗干预。Integrin alpha A1 beta 1 蛋白, Human (HEK293, His) 是重组的蛋白二聚体复合物，包含 整合素 α A1 β 1 蛋白，由 HEK293 表达，带有 C-His 标签。Integrin alpha A1 beta 1 蛋白, Human (HEK293, His) ，分子量为 160-200 kDa。

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100 μg   询价  

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描述

ITGA1 Protein, a cell surface receptor, plays a crucial role in cell adhesion, migration, and tissue development. Dysregulation of ITGA1 Protein has been linked to various diseases, including cancer and fibrosis. Targeting ITGA1 Protein may provide potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting tumor growth, and preventing tissue fibrosis. Integrin alpha A1 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha A1 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Human (HEK293, His), has molecular weight of 160-200 kDa.
研究背景

ITGA1 蛋白，也称为整合素 α-1/β-1，充当层粘连蛋白和胶原蛋白的受体。它专门识别胶原蛋白中的脯氨酸羟基化序列 GFPGER。此外，ITGA1 还参与 EGF 刺激的细胞生长的贴壁依赖性负调节。它与 β 亚基形成异二聚体，与 β-1 结合。ITGA1 还与 RAB21 和 PTPN2 相互作用，激活 PTPN2 磷酸酶对 EGFR 的活性，并对 EGF 信号传导发挥负调节作用。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

P56199-1 (F29-P1141)&P05556-1 (Q21-D728)
基因 ID

3672&3688
同用名
Integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; Integrin alpha A1 β 1; alpha A1 β 1; β 1
分子量

160-200 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Integrin alpha A1 beta 1 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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