2. 重组蛋白
  3. Enzymes & Regulators
  4. Oxidoreductases (EC 1)
  5. IVD 蛋白, Human (sf9, His)

IVD 蛋白, Human (sf9, His)

目录号: HY-P73857
产品使用指南

IVD是负责催化异戊酰辅酶A/3-甲基丁酰辅酶A转化为3-甲基丁-2-烯酰辅酶A的关键酶，这是亮氨酸分解代谢途径中重要的中间步骤。。这种酶活性对于支链氨基酸亮氨酸的分解至关重要，并有助于代谢过程的调节。IVD 蛋白, Human (sf9, His) 是重组的 IVD 蛋白，由 Sf9 insect cells 表达，带有 N-His 标签。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

IVD is a key enzyme responsible for catalyzing the conversion of isovaleryl-CoA/3-methylbutyryl-CoA into 3-methylbut-2-enoyl-CoA, which is an important intermediate step in the leucine catabolism pathway. . This enzyme activity is essential for the breakdown of the branched-chain amino acid leucine and contributes to the regulation of metabolic processes. IVD Protein, Human (sf9, His) is the recombinant human-derived IVD protein, expressed by Sf9 insect cells , with N-His labeled tag.
研究背景

异戊酰辅酶A脱氢酶（IVD）是亮氨酸分解代谢途径中的关键酶，催化异戊酰辅酶A/3-甲基丁酰辅酶A转化为3-甲基丁-2-烯酰辅酶A。该酶促步骤是亮氨酸分解的关键中间体。除了在亮氨酸代谢中的主要作用外，IVD 还具有氧化其他饱和短链酰基辅酶 A 硫酯的能力，包括戊酰辅酶 A、己烯酰辅酶 A 和丁烯酰辅酶 A，尽管程度较小。这些更广泛的底物能力表明，IVD 可能有助于各种短链脂肪酸的氧化，将其代谢作用扩展到亮氨酸分解代谢之外。IVD 的多功能性质强调了其通过参与多种酰基辅酶 A 底物的降解（改编自所提供的通道）来维持代谢稳态的重要性。
种属

Human
表达系统

Sf9 insect cells
标签

N-His
蛋白编号

P26440-1 (H33-H426)
基因 ID
蛋白结构
N-term
His
IVD (H33-H426)
Accession # P26440-1
C-term
同用名
Isovaleryl-CoA dehydrogenase, mitochondrial; IVD
分子量

Approximately 43 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

IVD Protein, Human (sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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