KGF/FGF-7 蛋白, Human (His)

KGF/FGF-7 proteins coordinate embryonic development and regulate basic processes such as cell proliferation and differentiation. Its critical role extends to normal branching morphogenesis. KGF/FGF-7 Protein, Human (His) is the recombinant human-derived KGF/FGF-7 protein, expressed by E. coli , with N-His labeled tag.

KGF/FGF-7 蛋白在协调胚胎发育中发挥着至关重要的作用，对细胞增殖和分化等基本过程具有调节控制作用。它的重要贡献延伸到正常分支形态发生的复杂领域，其中 KGF/FGF-7 发挥着关键作用。作为一种对角质形成细胞具有特异性活性的生长因子，它是控制正常上皮细胞增殖的潜在主要旁分泌效应物。该蛋白建立了关键的相互作用，与 FGFBP1 和 FGFR2 形成复合物，并且其与成纤维细胞生长因子 (FGF) 及其受体的结合亲和力通过硫酸乙酰肝素糖胺聚糖增强，在这些分子相互作用中充当关键的辅助受体。

Measured in a cell proliferation assay using 4MBr5 rhesus monkey epithelial cells. The ED₅₀ for this effect is 14.52 ng/mL, corresponding to a specific activity is 6.89×10⁴ units/mg.

Human

E. coli

N-His

P21781-1 (C32-T194)

2252  [NCBI]

Approximately 20.1 kDa

Greater than 95% as determined by Tris-Bis PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 50 mM Tris, 250 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.