KIR2DL5/CD158f 蛋白, Human (HEK293, Fc)

KIR2DL5/CD158f, present on NK cells, acts as a receptor for HLA-C alleles. Its inhibitory function finely tunes NK cell activity, preventing cell lysis by interacting with specific HLA-C molecules. This dynamic engagement contributes to the nuanced balance of inhibitory signals in the immune system, regulating NK cell responses to potential targets. KIR2DL5/CD158f Protein, Human (HEK293, Fc) is the recombinant human-derived KIR2DL5/CD158f protein, expressed by HEK293 , with C-hFc labeled tag.

KIR2DL5/CD158f 在自然杀伤 (NK) 细胞上表达，充当 HLA-C 等位基因的受体。该受体以抑制方式发挥作用，调节 NK 细胞活性以防止细胞裂解。通过与特定的 HLA-C 分子相互作用，KIR2DL5 有助于免疫系统中抑制信号的微妙平衡，微调 NK 细胞对潜在目标的反应。

Immobilized Human KIR2DL5 at 2 μg/mL (100 μL/well) can bind Anti- KIR2DL5 Antibody. The ED₅₀ for this effect is 1.558 μg/mL.

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  Immobilized Human KIR2DL5 at 2 μg/mL (100 μL/well) can bind Anti- KIR2DL5 Antibody. The ED₅₀ for this effect is 1.558 μg/mL.

Human

HEK293

C-hFc

Q8N109/NP_065396.1 (H22-H240)

57292  [NCBI]

HEGGQDKPLLSAWPSAVVPRGGHVTLLCRSRLGFTIFSLYKEDGVPVPELYNKIFWKSILMGPVTPAHAGTYRCRGSHPRSPIEWSAPSNPLVIVVTGLFGKPSLSAQPGPTVRTGENVTLSCSSRSSFDMYHLSREGRAHEPRLPAVPSVNGTFQADFPLGPATHGGTYTCFGSLHDSPYEWSDPSDPLLVSVTGNSSSSSSSPTEPSSKTGIRRHLH

Approximately 65 kDa due to the glycosylation

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.