LIF 蛋白, Mouse (HEK293, Fc)

LIF (Leukemia Inhibitory Factor) prompts terminal differentiation in leukemic cells, inducing hematopoietic and neuronal cell differentiation.It also stimulates acute-phase protein synthesis in hepatocytes.LIF's multifaceted role underscores its significance in regulating hematopoiesis, neurogenesis, and hepatic responses.LIF Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived LIF protein, expressed by HEK293 , with C-hFc labeled tag.

LIF（白血病抑制因子）具有促进白血病细胞终末分化的能力，具有多种活性。值得注意的是，它诱导正常细胞和髓性白血病细胞的造血分化，促进神经元细胞分化，并刺激肝细胞中急性期蛋白的合成。这种多方面的作用强调了 LIF 在协调各种细胞过程中的重要性，有助于调节造血、神经发生和肝脏反应。

Measured in a cell proliferation assay using C2C12 cells. The ED₅₀ for this effect is 0.3259 ng/mL, corresponding to a specific activity is 3.06×10⁶ units/mg.

Mouse

HEK293

C-hFc

P09056 (P25-F203)

16878  [NCBI]

65-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.