LRP-12 蛋白, Human (HEK293, His)

LRP-12, a probable receptor, potentially facilitates the internalization of lipophilic molecules and signal transduction. It may function as a tumor suppressor and interacts with proteins RACK1, ZFYVE9, and NMRK2. LRP-12 Protein, Human (HEK293, His) is the recombinant human-derived LRP-12 protein, expressed by HEK293 , with C-6*His labeled tag.

LRP-12 蛋白作为一种可能的受体出现，在亲脂性分子的内化和/或信号转导中具有潜在作用，暗示其在细胞过程中的重要性。此外，它还被认为具有肿瘤抑制因子的作用，强调了它在调节细胞生长和预防肿瘤发生方面的潜在作用。LRP-12 还表现出与 RACK1、ZFYVE9 和 NMRK2 等关键蛋白的相互作用，表明可能有助于其多样化细胞功能的关联网络。LRP-12 与各种分子的复杂相互作用表明其具有多功能作用，强调了其在细胞稳态中的重要性以及在疾病途径中的潜在影响。

Measured by its binding ability in a functional ELISA.When Recombinant Human LRP-12 is immobilized at 0.5 μg/mL, 100 μL/well can bind Recombinant Human LRPAP (HY-P76478). The ED₅₀ for this effect is 1.763 μg/mL.

Human

HEK293

C-6*His

Q9Y561-1 (E33-I488)

29967  [NCBI]

EHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI

Approximately 60-85 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2 or PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.