Lymphocyte antigen 86/LY86 蛋白, Human (HEK293, Fc)

Lymphocyte antigen 86/LY86 acts synergistically with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and influence cytokine production. It plays a crucial role in promoting the high expression of CD180 on the cell surface, forming an M-shaped tetramer with two CD180-LY86 heterodimers. Lymphocyte antigen 86/LY86 Protein, Human (HEK293, Fc) is the recombinant human-derived Lymphocyte antigen 86/LY86 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Lymphocyte antigen 86/LY86 Protein, Human (HEK293, Fc) is 142 a.a., with molecular weight of 45-55 kDa.

淋巴细胞抗原 86/LY86 蛋白作为 CD180 和 TLR4 的潜在合作者出现，介导对细菌脂多糖 (LPS) 的先天免疫反应并影响细胞因子的产生。此外，淋巴细胞抗原 86/LY86 在促进 CD180 细胞表面高效表达方面发挥着至关重要的作用。结构排列涉及 M 形四聚体的形成，其中包含两个 CD180-LY86 异二聚体。这些特征强调了淋巴细胞抗原 86/LY86 在协调免疫反应和细胞相互作用方面的多方面性质。进一步探索对于揭示淋巴细胞抗原 86/LY86 促进先天免疫系统复杂动态及其与 CD180 和 TLR4 协同响应细菌 LPS 的具体分子机制至关重要。

Human

HEK293

C-hFc

O95711 (G21-S162)

9450  [NCBI]

GGGGKAWPTHVVCSDSGLEVLYQSCDPLQDFGFSVEKCSKQLKSNINIRFGIILREDIKELFLDLALMSQGSSVLNFSYPICEAALPKFSFCGRRKGEQIYYAGPVNNPEFTIPQGEYQVLLELYTEKRSTVACANATIMCS

45-55 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.