2. 重组蛋白
  3. Cytokines and Growth Factors
  4. CSF & Receptors
  5. M-CSF
  6. M-CSF 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc)

M-CSF 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc)

目录号: HY-P73831
COA 产品使用指南

M-CSF 蛋白调节造血前体细胞，促进其存活、增殖和分化。M-CSF 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc) 是重组的 M-CSF 蛋白，由 HEK293 表达，带有 C-hFc 标签。M-CSF 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc) 全长 190 个氨基酸，分子量约为 ~45.1 kDa。

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规格 价格 是否有货 数量
50 μg ￥5200 In-stock
100 μg   询价  

* Please select Quantity before adding items.

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  • 生物活性

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描述

The M-CSF protein regulates hematopoietic precursor cells, promoting their survival, proliferation, and differentiation. M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque, cynomolgus-derived M-CSF protein, expressed by HEK293 , with C-hFc labeled tag. The total length of M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 190 a.a., with molecular weight of ~45.1 kDa.
研究背景

M-CSF 蛋白在协调造血前体细胞（特别是单核吞噬细胞，包括巨噬细胞和单核细胞）的生存、增殖和分化的调节中发挥着至关重要的作用。其重要性延伸到促进促炎趋化因子的释放，从而在先天免疫和炎症过程中发挥关键作用。此外，M-CSF 在调节破骨细胞增殖和分化、影响骨吸收并有助于正常骨发育方面发挥着关键作用。除了对骨骼系统的影响之外，M-CSF 对于正常男性和女性的生育能力也是不可或缺的。细胞因子还在脂蛋白清除中发挥作用，并有助于细胞过程，例如重组肌动蛋白细胞骨架、调节膜皱褶的形成、细胞粘附和细胞迁移。M-CSF可以多种形式存在，包括具有两个相同的150-200kDa蛋白聚糖亚基的同二聚体、具有150-200kDa蛋白聚糖亚基和截短的43kDa亚基的异二聚体、以及具有两个相同的43kDa亚基的同二聚体。它与其受体 CSF1R 相互作用以发挥其多种功能。
生物活性

Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cell. The ED50 for this effect is typically 25-140 ng/mL.
种属

Cynomolgus
表达系统

HEK293
标签

C-hFc
蛋白编号

XP_005542489 (M1-P190)
基因 ID
蛋白结构
N-term
M-CSF (M1-P190)
Accession # XP_005542489
hFc
C-term
同用名
Macrophage Colony-Stimulating Factor 1; CSF-1; M-CSF; Lanimostim
分子量

Approximately 45.1 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末.
组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
运输条件

Room temperature in continental US; may vary elsewhere.
文件资料

COA (210 KB)

产品使用指南 (1213 KB)

M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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