2. 重组蛋白
  3. Cytokines and Growth Factors
  4. CSF & Receptors
  5. M-CSF R
  6. CSF1R 蛋白, Human (498a.a, HEK293, His)

CSF1R 蛋白, Human (498a.a, HEK293, His)

目录号: HY-P72509
COA 产品使用指南

CSF1R蛋白普遍存在于单核吞噬细胞，特别是巨噬细胞和单核细胞中，并参与多种生物过程。它响应 IL34 和 CSF1 诱导促炎趋化因子的释放，有助于先天免疫和炎症。CSF1R 蛋白, Human (498a.a, HEK293, His) 是重组的 CSF1R 蛋白，由 HEK293 表达，带有 C-6*His 标签。CSF1R 蛋白, Human (498a.a, HEK293, His) 全长 498 个氨基酸，分子量为 80-110 kDa。

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规格 价格 是否有货 数量
10 μg ￥850 In-stock
50 μg ￥1780 In-stock
100 μg   询价  

* Please select Quantity before adding items.

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  • 生物活性

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描述

CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (498a.a, HEK293, His) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CSF1R Protein, Human (498a.a, HEK293, His) is 498 a.a., with molecular weight of 80-110 kDa.
研究背景

CSF1R 蛋白尤其存在于巨噬细胞和单核细胞等单核吞噬细胞中，参与多种生物过程。它响应 IL34 和 CSF1 促进促炎趋化因子的释放，有助于先天免疫和炎症过程。此外，CSF1R 对于调节破骨细胞增殖和分化、骨吸收、正常骨骼和牙齿发育至关重要。它也是男性和女性正常生育能力以及怀孕期间乳腺中乳管和腺泡结构发育所必需的。
生物活性

Measured by its binding ability in a functional ELISA. Immobilized Human CSF1R at 5 μg/mL (100 μL/well) can bind Biotinylated Human M-CSF. The ED50 for this effect is 24.66 ng/mL.

种属

Human
表达系统

HEK293
标签

C-6*His
蛋白编号

P07333-1 (I20-P517)
基因 ID
蛋白结构
N-term
CSF1R (I20-P517)
Accession # P07333-1
6*His
C-term
同用名
Macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS
氨基酸序列

IPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTP

分子量

80-110 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末.
组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
运输条件

Room temperature in continental US; may vary elsewhere.
文件资料

COA (209 KB)

产品使用指南 (1213 KB)

CSF1R Protein, Human (498a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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