Serpin B5/Maspin 蛋白, Human (375 a.a)

Serpin B5/Maspin Protein, Human (375 a.a) could inhibit invasion and motility of mammary tumors. Maspin Protein, Human is also found to be a potent angiogenesis inhibitor.

Maspin 是丝氨酸蛋白酶抑制剂家族的独特成员，与单核细胞-中性粒细胞弹性蛋白酶抑制剂、PAI-2 和其他丝氨酸蛋白酶抑制剂具有广泛的同源性。Maspin 已被证明可以抑制乳腺肿瘤的侵袭和运动。表达maspin的肿瘤转染子在裸鼠中表现出生长和转移减少。大多数乳腺肿瘤中未检测到 Maspin 基因表达，其表达缺失与肿瘤侵袭性相关。Maspin 还被发现是一种有效的血管生成抑制剂。在人类乳腺组织中，maspin 似乎比肌上皮细胞更多地存在于管腔中，并且有人提出，那些表达 maspin 的肌上皮细胞形成了从导管原位癌发展为更具侵袭性的癌的防御屏障。生物化学家对于 maspin 是否充当蛋白酶抑制剂存在争议^[1]。

Human

E. coli

Tag Free

P36952-1 (M1-P375)

5268  [NCBI]

MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDIPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFPESETKECPFRLNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP

Approximately 38-47 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Ming Zhang, et al. The Role of Maspin in Tumor Progression and Normal Development. Madame Curie Bioscience Database [Internet].