MBL1 蛋白, Mouse (HEK293, His)

MBL1, a calcium-dependent lectin, recognizes microbial moieties, activating the lectin complement pathway.It also binds apoptotic and necrotic cells, aiding uptake by macrophages.As a homotrimer, MBL1 forms higher oligomeric complexes in the endoplasmic reticulum.MBL1's interaction with MASP1 and MASP2 enhances its role in immune response modulation and cellular recognition.MBL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MBL1 protein, expressed by HEK293 , with N-His, N-6*His labeled tag.

MBL1 是一种钙依赖性凝集素，通过识别各种微生物上的甘露糖、岩藻糖和 N-乙酰氨基葡萄糖部分，从而激活凝集素补体途径，在先天免疫反应中发挥至关重要的作用。除了与微生物的相互作用外，MBL1 还与晚期凋亡细胞、凋亡泡和坏死细胞结合，促进巨噬细胞对其的摄取。MBL1 作为同源三聚体存在，通过两个、三个或更多同源三聚体的结合进一步组装成更高级的寡聚复合物，这一过程发生在内质网中。此外，MBL1 与 MASP1 和 MASP2 相互作用，进一步促进其参与免疫反应调节和细胞识别过程。

Mouse

HEK293

N-6*His

P39039/NP_034905.1 (S21-A239)

17194  [NCBI]

SQTCEDTLKTCSVIACGRDGRDGPKGEKGEPGQGLRGLQGPPGKLGPPGSVGSPGSPGPKGQKGDHGDNRAIEEKLANMEAEIRILKSKLQLTNKLHAFSMGKKSGKKLFVTNHEKMPFSKVKSLCTELQGTVAIPRNAEENKAIQEVATGIAFLGITDEATEGQFMYVTGGRLTYSNWKKDEPNNHGSGEDCVIILDNGLWNDISCQASFKAVCEFPA

Approximately 32 kDa.

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.