MCD 蛋白, Human (His)

MCD proteins catalyze the conversion of malonyl-CoA to acetyl-CoA, ensuring that only methylmalonyl-CoA serves as a substrate for fatty acid synthase, producing fatty acids with multiple methyl side chains. MCD Protein, Human (His) is the recombinant human-derived MCD protein, expressed by E. coli , with N-6*His labeled tag. The total length of MCD Protein, Human (His) is 452 a.a., .

MCD 蛋白通过催化丙二酰辅酶 A 转化为乙酰辅酶 A，在细胞代谢中发挥关键作用。MCD 在脂肪酸生物合成中特别重要，它选择性地消除丙二酰辅酶 A，确保甲基丙二酰辅酶 A 成为脂肪酸合酶的唯一底物。这种选择性去除机制有助于产生具有多个甲基侧链的脂肪酸。在过氧化物酶体中，MCD 参与过氧化物酶体内丙二酰辅酶 A 的降解，丙二酰辅酶 A 是奇数链长二羧酸脂肪酸的过氧化物酶体 β 氧化的副产物。除了参与脂质代谢之外，MCD 还影响肌肉中葡萄糖和脂质氧化之间的代谢平衡，与胰岛素信号传导的改变无关。此外，MCD 可能通过促进葡萄糖氧化而在减轻缺血性损伤中发挥作用，突显其对细胞功能和代谢途径的多方面影响。

Human

E. coli

N-6*His

O95822 (M40-S491)(E58A, K59A, E278A, E279A, K280A)

23417

Approximately 52.4 KDa.

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 200 mM NaCl, 20% glycerol, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.