MDC/CCL22 蛋白, Rat

CCL22/MDC Protein, Rat is a CC chemokine that acts as a ligand for the CCR4 receptor and is a chemoattractant for CCR4-expressing cells such as Th2 cells, playing an important role in homeostatic and inflammatory responses. CCL22/MDC Protein, Rat is a recombinant rat CCL22/MDC(G25-A92) protein expressed by E. coli^[1][2].

CCL22又称巨噬细胞源性趋化因子（MDC），是一种位于人类基因组16号染色体上的CC趋化因子，是由CCL22基因编码的蛋白质，在氨基酸水平上与CCL17有37%的同一性。CCL22由树突状细胞和巨噬细胞分泌，可被脂多糖、细胞因子等多种刺激因子上调。其中，Th2细胞因子IL-4和IL-13诱导骨髓细胞产生CCL22，并可被Th1细胞因子IFN-γ抑制。除了作为表达 CCR4 的 Th2 淋巴细胞、单核细胞、单核细胞衍生的树突细胞和自然杀伤细胞的有效趋化剂外，CCL22 还可以通过与趋化因子受体 CCR4 相互作用来影响其靶细胞。CCL22是CCR4内化的有效诱导剂，CCL22与CCR4的结合降低了CCR4随后的功能反应。CCL22 与 CCR4 的相互作用涉及多种病理学，从过敏反应、自身免疫到肿瘤生长。相比之下，能够阻断 CCL17 和 CCL22 介导的 Th2 和 Treg 细胞募集的小分子化合物和抗体已被证明在哮喘、特应性疾病和肿瘤生长的各种疾病模型中具有积极作用。此外，CCL22 及其受体在 TH2 淋巴细胞募集中的重要作用已在过敏性气道炎症模型中得到证实。它还可以通过调节成熟胸腺细胞通过该器官的迁移来参与胸腺生成^[1][2]。

CCL22 expression is selectively upregulated in the rat model of radiation pneumonia/pulmonary fibrosis, and increased CCL22 expression is also observed in some alveolar macrophages in the lungs of the radiotherapy group^[3].

Rat

E. coli

Tag Free

Q5I0L5 (G25-A92)

117551  [NCBI]

GPYGANVEDSICCQDYIRHPLPPRFVKEFYWTSKSCRKPGVVLITIKNRDICADPRMLWVKKILHKLA

Approximately 7.9 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Jan Korbecki, et al. CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4. Int J Mol Sci. 2020 Nov 9;21(21):8412.  [Content Brief]

  [2]. Yano C, et al. Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Keratinocytes. Ann Dermatol. 2015 Apr;27(2):152-6.  [Content Brief]

  [3]. Stefanie Scheu, et al. The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity. Int J Mol Sci. 2017 Nov 2;18(11):2306.  [Content Brief]

  [4]. T Inoue, et al. CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis. Eur Respir J. 2004 Jul;24(1):49-56.  [Content Brief]