1. 重组蛋白
  2. Receptor Proteins Enzymes & Regulators
  3. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. TAM Receptor
  5. Mer Proteins Mer Proteins
  6. Mer 蛋白, Human (sf9, His-GST)

Mer 蛋白, Human (sf9, His-GST)

目录号: HY-P73821
产品使用指南

Mer 蛋白是一种受体酪氨酸激酶,通过与 LGALS3、TUB、TULP1 或 GAS6 等配体结合来转导信号,调节细胞存活、迁移、分化和凋亡细胞吞噬作用(胞吞作用)。配体结合诱导 MERTK 自身磷酸化,为下游分子创建对接位点。Mer 蛋白, Human (sf9, His-GST) 是重组的 Mer 蛋白,由 Sf9 insect cells 表达,带有 N-His, N-GST 标签。Mer 蛋白, Human (sf9, His-GST) 全长 295 个氨基酸,分子量约为 ~50 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (sf9, His-GST) is the recombinant human-derived Mer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Mer Protein, Human (sf9, His-GST) is 295 a.a., with molecular weight of ~50 kDa.

研究背景

Mer 蛋白是一种受体酪氨酸激酶,通过与各种配体(包括 LGALS3、TUB、TULP1 或 GAS6)结合来转导来自细胞外基质的信号。它参与调节多种生理过程,包括细胞存活、迁移、分化和凋亡细胞的吞噬作用(胞吞作用)。细胞表面的配体结合诱导 MERTK 在其胞内结构域上的自身磷酸化,为下游信号分子创建对接位点。被配体激活后,Mer 与 GRB2 或 PLCG2 相互作用并诱导 MAPK1、MAPK2、FAK/PTK2 或 RAC1 磷酸化。MERTK 信号传导涉及巨噬细胞清除凋亡细胞、血小板聚集、细胞骨架重组和吞噬。在视网膜色素上皮(RPE)中,它充当视杆细胞外节片段吞噬作用的调节器。此外,Mer 在通过激活 STAT1 抑制 Toll 样受体 (TLR) 介导的先天免疫反应中发挥着至关重要的作用,STAT1 选择性诱导细胞因子信号转导 SOCS1 和 SOCS3 抑制剂的产生。

种属

Human

表达系统

Sf9 insect cells

标签

N-His;N-GST

蛋白编号

Q12866 (E578-Y872)

基因 ID
蛋白结构
N-term
His-GST
Mer (E578-Y872)
Accession # Q12866
C-term
同用名
Tyrosine-protein kinase Mer; MERTK; MER
分子量

Approximately 50 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Mer Protein, Human (sf9, His-GST)
目录号:
HY-P73821
需求量: