MERS-CoV Spike/S1 蛋白 (CHO, hFc)

MERS-CoV Spike/S1 Proteinas, a crucial component of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), mediates viral entry into host cells by binding to the host receptor DPP4. The Spike/S1 protein initiates the infection process and is a key target for antiviral strategies. Understanding its structure and interactions is vital for developing effective interventions against MERS-CoV. MERS-CoV Spike/S1 Protein (CHO, hFc) is the recombinant Virus-derived MERS-CoV Spike/S1 protein, expressed by CHO , with C-hFc labeled tag.

ABCD2 是一种 ATP 依赖性转运蛋白，属于 ATP 结合盒 (ABC) 家族，在促进极长链脂肪酸 (VLCFA)-CoA 从细胞质转运到过氧化物酶体腔中发挥着至关重要的作用。与 ABCD1 类似，ABCD2 表现出脂肪酰辅酶 A 硫酯酶 (ACOT) 和 ATP 酶活性。根据提出的模型，在 VLCFA-CoA 水解后，VLCFA-CoA 以 ATP 依赖性方式转运到过氧化物酶体中，由 ABCD2 的 ACOT 活性介导（可能）。值得注意的是，ABCD2 与 ABCD1 具有重叠的底物特异性，特别是针对饱和脂肪酸 (FA) 和单不饱和 FA (MUFA)。然而，如体外观察到的，ABCD2 对较短的 VLCFA (C22:0) 和多不饱和脂肪酸 (PUFA)（例如 C22:6-CoA 和 C24:6-CoA）表现出明显的底物偏好。这种底物特异性表明 ABCD2 在极长链脂肪酸 (VLCFA) 和能量代谢中具有潜在的调节作用，特别是在脂肪酸通过 β 氧化的降解和生物合成中。

Measured by its binding ability in a functional ELISA. When Recombinant Human DPPIV/CD26 (HY-P72975) is present at 5 μg/mL can bind Recombinant MERS-CoV Spike/S1. The ED₅₀ for this effect is 0.4222 μg/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Human DPPIV/CD26 (HY-P72975) is present at 5 μg/mL can bind Recombinant MERS-CoV Spike/S1. The ED₅₀ for this effect is 0.4222 μg/mL.

Virus

CHO

C-hFc

K9N5Q8 (Y18-P747)

1489668

YVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTPQKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGITQTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIPHSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCSRFLSDDRTEVPQLVNANQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSVPVSVIYDKETKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGPLQTPVGCVLGLVNSSLFVEDCKLPLGQSLCALPDTPSTLTP

110-135 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 500 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.