METAP1D/Methionine aminopeptidase 1D 蛋白, Human (His)

METAP1D or methionine aminopeptidase 1D plays a crucial role in protein maturation, catalyzing the removal of N-terminal methionine from nascent proteins. Its activity is prominent in the smaller, uncharged second residue (Met-Ala, Cys, Gly, Pro, Ser, Thr or Val). METAP1D/Methionine aminopeptidase 1D Protein, Human (His) is the recombinant human-derived METAP1D/Methionine aminopeptidase 1D protein, expressed by E. coli , with N-6*His, C-6*His labeled tag. The total length of METAP1D/Methionine aminopeptidase 1D Protein, Human (His) is 292 a.a., with molecular weight of 35-40 kDa.

METAP1D，称为蛋氨酸氨肽酶 1D，通过催化新生蛋白质中 N 末端蛋氨酸的去除，在蛋白质成熟中发挥关键作用。当一级序列中的第二个残基较小且不带电荷时，例如 Met-Ala、Cys、Gly、Pro、Ser、Thr 或 Val，这种酶活性尤其普遍。值得注意的是，METAP1D 的功能需要预先对 N(α)-甲酰化引发剂蛋氨酸进行去甲酰化，以实现随后的水解。除了在蛋白质生物合成中的作用之外，METAP1D 还可能与结肠肿瘤发生有关，这表明它参与更广泛的细胞过程以及对病理状况的潜在影响。

Human

E. coli

N-6*His;C-6*His

Q6UB28 (R44-A335)

254042  [NCBI]

RQRDISHSIVLPAAVSSAHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA

35-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.