2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. MGAT2 蛋白, Human (HEK293, His)

MGAT2 蛋白, Human (HEK293, His)

目录号: HY-P70410
产品使用指南

MGAT2 蛋白在蛋白质 N-糖基化中发挥重要作用，催化 GlcNAc 转移至新生 N-连接聚糖链中的游离末端甘露糖。这形成了复杂聚糖的第二个分支，对于糖蛋白的成熟和功能多样性至关重要。MGAT2 蛋白, Human (HEK293, His) 是重组的 MGAT2 蛋白，由 HEK293 表达，带有 C-6*His 标签。MGAT2 蛋白, Human (HEK293, His) 全长 418 个氨基酸，分子量约为 ~50.0 kDa。

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100 μg   询价  

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描述

The MGAT2 protein plays an important role in protein N-glycosylation, catalyzing the transfer of GlcNAc to the free terminal mannose in nascent N-linked glycan chains. This forms a second branch of the complex glycan and is critical for glycoprotein maturation and functional diversity. MGAT2 Protein, Human (HEK293, His) is the recombinant human-derived MGAT2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MGAT2 Protein, Human (HEK293, His) is 418 a.a., with molecular weight of ~50.0 kDa.
研究背景

MGAT2 蛋白在蛋白质 N-糖基化中发挥重要作用，促进新生聚糖链修饰的关键步骤。具体来说，MGAT2 催化 N-乙酰氨基葡萄糖 (GlcNAc) 转移到新生 N-连接聚糖链核心结构内的游离末端甘露糖部分上。这种酶活性导致复杂聚糖中第二个分支的形成，这是糖蛋白正常成熟和功能多样性所必需的过程。通过介导这一糖基化步骤，MGAT2 在控制蛋白质修饰的复杂机制中发挥着核心作用，有助于对整体生物活性至关重要的细胞过程和功能。
种属

Human
表达系统

HEK293
标签

C-6*His
蛋白编号

Q10469 (R30-Q447)
基因 ID
蛋白结构
N-term
MGAT2 (R30-Q447)
Accession # Q10469
6*His
C-term
同用名
rHuAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase/MGAT2, His ; Alpha-1; 6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase; Beta-1; 2-N-acetylglucosaminyltransferase II; GlcNAc-T II; NT-II; Mannoside Acetylglucosaminyltransferase 2; N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase II; MGAT2
氨基酸序列

RQRKNEALAPPLLDAEPARGAGGRGGDHPSVAVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSFYGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVVAISPPRKNGGWGDIRDHELCKSYRRLQ

分子量

Approximately 50.0 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

MGAT2 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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