MPZL1 蛋白, Human (HEK293, His)

MPZL1 protein is a cell surface receptor that participates in signal transduction by recruiting PTPN11/SHP-2 to the cell membrane. MPZL1 Protein, Human (HEK293, His) is the recombinant human-derived MPZL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MPZL1 Protein, Human (HEK293, His) is 127 a.a., with molecular weight of 20-28 kDa.

MPZL1 是一种复杂参与信号转导过程的细胞表面受体，在将 PTPN11/SHP-2 募集到细胞膜方面发挥着关键作用，将其自身确立为 PTPN11/SHP-2 的推定底物。作为刀豆蛋白 A (ConA) 的主要受体，MPZL1 有助于 ConA 诱导的细胞信号传导，可能涉及 Src 家族酪氨酸蛋白激酶。同工型 3 变体似乎发挥显性负效应，抑制 ConA 诱导的 MPZL1 酪氨酸磷酸化。值得注意的是，同工型 1 与同工型 2 和同工型 3 不同，涉及整合素介导的细胞运动的调节。该受体还与磷酸化 PTPN11/SHP-2 相互作用，强调其在信号转导级联中的多方面参与。

Human

HEK293

C-6*His

O95297 (S36-V162)

9019  [NCBI]

SALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPV

20-28 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.