MRAP 蛋白, Human (HEK293, hFc)

MRAP protein crucially modulates melanocortin receptors (MC1R, MC2R, MC3R, MC4R, and MC5R), enhancing ligand sensitivity and amplifying cAMP generation. Its role extends to promoting MC2R cell surface expression in adrenal cells for corticotropin (ACTH) signaling and potential involvement in adipocyte intracellular trafficking pathways. MRAP forms antiparallel homodimers and heterodimers, engaging with a range of melanocortin receptors. MRAP Protein, Human (HEK293, hFc) is the recombinant human-derived MRAP protein, expressed by HEK293 , with N-hFc labeled tag.

MRAP 蛋白是黑皮质素受体（MC1R、MC2R、MC3R、MC4R 和 MC5R）的重要调节剂，通过增强配体敏感性和响应受体激活而放大 cAMP 生成来发挥其作用。它在促进肾上腺细胞中 MC2R 的细胞表面表达、促进促肾上腺皮质激素 (ACTH) 信号传导方面发挥着至关重要的作用。此外，MRAP 可能参与脂肪细胞内的细胞内运输途径。该蛋白形成同二聚体和异二聚体，均作为反平行结构，并与一系列黑皮质素受体（即 MC1R、MC2R、MC3R、MC4R 和 MC5R）相互作用。

Human

HEK293

N-hFc

Q8TCY5-4 (Y59-S172)

56246  [NCBI]

Approximately 40.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.