Muellerian-inhibiting factor/AMH 蛋白, Human (HEK293, His)

The Müllerian inhibitor/AMH protein plays a crucial role in reproductive processes. It induces degeneration of Müllerian ducts during male fetal sex differentiation and contributes to Leydig cell function. Muellerian-inhibiting factor/AMH Protein, Human (HEK293, His) is the recombinant human-derived Muellerian-inhibiting factor/AMH protein, expressed by HEK293 , with N-His labeled tag. The total length of Muellerian-inhibiting factor/AMH Protein, Human (HEK293, His) is 536 a.a., with molecular weight of ~59.1 kDa.

苗勒管抑制因子/AMH 蛋白在多种生殖功能中发挥着至关重要的作用。具体来说，它在男性胎儿性别分化过程中诱导缪勒管退化。它还以类似的方式促进间质细胞的分化和功能。在女性中，它充当从原始卵泡到初级卵泡过渡的负调节因子，并降低生长中的卵泡对卵泡刺激激素的敏感性。AMH 通过与特定的 II 型受体 AMHR2 结合来发挥其信号，AMHR2 与 I 型受体（ACVR1 和 BMPR1A）形成异二聚体。该复合物招募 SMAD 蛋白，促进其易位至细胞核以调节靶基因的表达。AMH 本身通过二硫键形成同二聚体。

Human

HEK293

N-His

NP_000470.2 (L25-R560)

268  [NCBI]

Approximately 59.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.