MVK 蛋白, Human (sf9, His-GST)

MVK (mevalonate kinase) protein plays a vital role in cellular metabolism by catalyzing the phosphorylation of mevalonate to mevalonate 5-phosphate, which is responsible for isoprenoid and cholesterol biosynthesis. key step. MVK regulates pathways necessary for the synthesis of important cellular components. MVK Protein, Human (sf9, His-GST) is the recombinant human-derived MVK protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of MVK Protein, Human (sf9, His-GST) is 396 a.a., with molecular weight of ~47 kDa.

MVK 蛋白通过催化甲羟戊酸磷酸化为甲羟戊酸 5-磷酸，在类异戊二烯和胆固醇生物合成中发挥关键作用。这种酶活性代表了甲羟戊酸途径中至关重要的限速步骤，甲羟戊酸途径是合成各种重要分子（包括胆固醇和类异戊二烯化合物）所必需的代谢途径。MVK 对甲羟戊酸的磷酸化是一个严格调控的过程，也是细胞内胆固醇和类异戊二烯生成总体控制的关键调控点。MVK 活性失调与某些代谢紊乱有关，强调了这种酶在维持细胞稳态和脂质代谢中的重要性。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

Sf9 insect cells

N-His;N-GST

Q03426 (M1-L396)

4598  [NCBI]

Approximately 47 kDa

Greater than 85% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 2 mM DTT, pH 7.4, 10% gly.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.