MYD88 蛋白, Human

The MYD88 protein is a key adapter in Toll-like receptor (TLR) and IL-1 receptor signaling and can activate NF-kappa-B, cytokine secretion and inflammatory responses through IRAK1, IRAK2, IRF7 and TRAF6. It enhances IL-8 transcription and participates in IL-18-mediated pathways. MYD88 Protein, Human is the recombinant human-derived MYD88 protein, expressed by E. coli , with tag free. The total length of MYD88 Protein, Human is 140 a.a., .

MYD88 蛋白作为衔接蛋白，在先天免疫反应中的 Toll 样受体 (TLR) 和 IL-1 受体信号通路中发挥着至关重要的作用。MYD88 通过 IRAK1、IRAK2、IRF7 和 TRAF6 发挥作用，触发 NF-kappa-B 激活、细胞因子分泌和炎症反应。此外，它还能增强 IL-8 转录并参与 IL-18 介导的信号通路。MYD88 激活 IRF1，促进其快速易位到细胞核中，从而有效诱导 IFN-β、NOS2/INOS 和 IL12A 基因。值得注意的是，来自 SARS-CoV-2、SARS-CoV 和 HIV-1 等病毒的富含 GU 的单链 RNA 激活 TLR8 后，MYD88 通过 NLRP3 炎性体激活诱导 IL1B 释放。在肠上皮细胞中，MYD88 介导的信号传导对于维持肠道稳态和调节小肠中抗菌凝集素 REG3G 的表达至关重要。MYD88 与 TIRAP 形成同二聚体和异二聚体，结合 TLR2、TLR4、TLR5、IRAK1、IRAK2、IRAK4，并与多种蛋白质相互作用，包括 IL18R1、BMX、IL1RL1、IKBKE、IRF7、LRRFIP1、LRRFIP2、FLII、IRF1、PELI1 和DHX9 等，从而编排涉及不同信号通路的分子相互作用的复杂网络。

Human

E. coli

Tag Free

Q99836 (M157-P296)

4615

Approximately 16.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH7.5, 200 mM NaCl, 20% glycerol.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.