NCAM-1/CD56 蛋白, Human (HEK293, His, solution)

Neural cell adhesion molecule 1 (NCAM1) is a cell adhesion molecule which enables LRR domain binding activity and phosphatase binding activity. NCAM1 plays a role in the cell development and differentiation as well as immune surveillance. NCAM1 plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and activating FAK, MAPK and PI3K. NCAM-1/CD56 Protein, Human (HEK293, His, solution) is the recombinant human-derived NCAM-1/CD56 protein, expressed by HEK293 , with C-His labeled tag. The total length of NCAM-1/CD56 Protein, Human (HEK293, His, solution) is 584 a.a., with molecular weight of ~66.1 kDa.

神经细胞黏附分子 1 (NCAM1) 是一种细胞黏附分子，属于免疫球蛋白超家族成员，具有 LRR 结构域结合活性和磷酸酶结合活性，参与同型细胞间黏附、正向调节钙介导的信号传导和调节外囊泡组装。
NCAM1 参与发育和分化过程中的细胞间相互作用以及细胞-基质相互作用，通过调节神经发生、神经突生长和细胞迁移在神经系统发育中发挥作用。NCAM1 还参与连合神经元的轴突导向和 semaphorin-plexin 信号通路的调节。此外，NCAM1 与 T 淋巴细胞、B 淋巴细胞和 NK 细胞的扩增有关，这些细胞在免疫监视中发挥重要作用。NCAM1 通过与成纤维细胞生长因子受体、N-钙黏蛋白和细胞外基质的其他成分相互作用，并通过触发包括 FYN -黏着斑激酶 (FAK)、丝裂原活化蛋白激酶 (MAPK)和磷脂酰肌醇3-激酶 (PI3K)的信号级联，在信号转导中发挥作用。
NCAM1 基因通过可变剪切具有多种蛋白亚型。NCAM1 的一个突出亚型是细胞表面分子 CD56，它在几种骨髓增殖性疾病 (如急性髓系白血病) 中发挥作用，并且 CD56 的差异表达与不同的疾病进展相关。例如，在急性髓系白血病患者中，CD56 表达增加与生存率降低相关，而 COVID-19 严重程度增加与外周血中表达 CD56 的 NK 细胞丰度降低相关。
NCAM1还作为狂犬病病毒和寨卡病毒的受体发挥作用^[1][2]。

Human

HEK293

C-His

P13591-3 (L20-P603)

4684  [NCBI]

Approximately 66.1 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.