2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens Receptor Proteins Biotinylated Proteins
  4. Inhibitory Checkpoint Molecules Stimulatory Immune Checkpoint Molecules NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. Immunoglobulin-like Cell Adhesion Molecules
  6. Nectin-2/CD112
  7. Nectin-2/CD112 蛋白, Human (HEK293, His-Avi)

Nectin-2/CD112 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78495
产品使用指南

Nectin-2/CD112 蛋白在 T 细胞信号传导中具有双重作用：作为 CD226 的共刺激剂，促进增殖和细胞因子的产生，并作为 PVRIG 的共抑制剂，抑制增殖。它还充当细胞粘附蛋白和某些病毒的受体。Nectin-2/CD112 蛋白, Human (HEK293, His-Avi) 是重组的 Nectin-2/CD112 蛋白，由 HEK293 表达，带有 C-His, C-Avi 标签。

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描述

Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
研究背景

Nectin-2/CD112 是一种 T 细胞信号传导的多功能调节剂，根据其所结合的受体，具有共刺激剂或共抑制剂的双重作用。与 CD226 结合可促进 T 细胞增殖和细胞因子产生，包括 IL2、IL5、IL10、IL13 和 IFNG 等关键因子。相比之下，与 PVRIG 的相互作用会抑制 T 细胞增殖，并且这些相互作用本质上是竞争性的。此外，如先前的研究所示，Nectin-2/CD112 可能是一种细胞粘附蛋白。此外，在微生物感染的情况下，它充当单纯疱疹病毒 1 (HHV-1) 突变体 Rid1、单纯疱疹病毒 1 (HHV-2) 和伪狂犬病病毒 (PRV) 的受体。
种属

Human
表达系统

HEK293
标签

C-His;C-Avi
蛋白编号

Q92692-2 (Q32-L360)
基因 ID
蛋白结构
N-term
CD112 (Q32-L360)
Accession # Q92692-2
His-Avi
C-term
同用名
CD112; MPH; Nectin2; PRR2; PVRL2; HVEB; PVRR2
分子量

45-52 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Nectin-2/CD112 Protein, Human (HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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