NECTIN2 - nectin cell adhesion molecule 2 Gene

中文名称：粘连蛋白细胞粘附分子 2

种属: Homo sapiens

同用名: HVEB; PRR2; CD112; PVRL2; PVRR2

基因 ID: 5819 | 基因类型: protein coding

关于 NECTIN2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,846,297-44,889,223 (from NCBI)

This gene has 6 transcripts (splice variants), 428 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 24.8), testis (RPKM 23.6) and 25 other tissues.

功能概要

该基因编码单程 I 型膜糖蛋白，具有两个 Ig 样 C2 型结构域和一个 Ig 样 V 型结构域。这种蛋白质是粘附连接的质膜成分之一。它还作为单纯疱疹病毒和伪狂犬病毒的某些突变株的入口，并参与这些病毒的细胞间传播。该基因的变异与多发性硬化症严重程度的差异有关。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

NECTIN2 基因产物(2)

mRNA	Protein	Name
NM_001042724.2	NP_001036189.1	nectin-2 isoform delta precursor
NM_002856.3	NP_002847.1	nectin-2 isoform alpha precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cell adhesion molecule binding	IPI IPI: 通过物理相互作用推断	9845526	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	21982860	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	9845526	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adhesion of symbiont to host	IDA IDA: 通过直接分析推断	12915581	GOA
involved in coreceptor-mediated virion attachment to host cell	IDA IDA: 通过直接分析推断	12915581	GOA
involved in fusion of virus membrane with host plasma membrane	IDA IDA: 通过直接分析推断	12915581	GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: 通过直接分析推断	9845526	GOA
involved in positive regulation of T cell receptor signaling pathway	IDA IDA: 通过直接分析推断	26755705	GOA
involved in positive regulation of immunoglobulin mediated immune response	IMP IMP: 通过突变表型推断	16831868	GOA
involved in positive regulation of mast cell activation	IMP IMP: 通过突变表型推断	16831868	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: 通过突变表型推断	16304049	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP IMP: 通过突变表型推断	12913096	GOA
involved in regulation of viral entry into host cell	IDA IDA: 通过直接分析推断	11602758	GOA
involved in susceptibility to T cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	15039383	GOA
involved in susceptibility to natural killer cell mediated cytotoxicity	IMP IMP: 通过突变表型推断	12913096	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	16831868	GOA
located in cell-cell junction	IDA IDA: 通过直接分析推断	9845526	GOA
located in membrane	IDA IDA: 通过直接分析推断	12913096	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NECTIN2 蛋白结构

V-set

C2-set_2

Ig_2

0
100
200
300
400
500
538 a.a.

蛋白主名

其他名称

nectin-2

herpesvirus entry protein B

NECTIN2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NECTIN2	Q92692	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
种属内	NECTIN2	Q92692	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
种属内	NECTIN2	Q92692	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
种属内	NECTIN2	Q92692	NECTIN3	Homo sapiens	Q9NQS3	SPR	23758976
种属内	NECTIN2	Q92692	NECTIN3	Homo sapiens	Q9NQS3	Protein Array	21982860
种属内	NECTIN2	Q92692	AFDN	Homo sapiens	P55196	Anti Bait CoIP	23750010
种属内	NECTIN2	Q92692	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
种属内	NECTIN2	Q92692	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
种属内	NECTIN2	Q92692	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
种属内	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	Solution Sedimentation	22902367
种属内	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	GMS	22927415
种属内	NECTIN2	Q92692	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
种属内	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	SPR	22902367
种属内	NECTIN2	Q92692	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
种属内	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	GMS	28515320
种属内	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	ELISA	23758976
种属内	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	Solution Sedimentation	22927415
种属内	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	Protein Array	21982860
种属内	NECTIN2	Q92692	NECTIN2	Homo sapiens	Q92692	X-Ray Diffraction	22927415
种属内	NECTIN2	Q92692	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
种属内	NECTIN2	Q92692	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NECTIN2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7780	Nectin-2/CD112 Protein, Human (HEK293, His)	Q92692-2 (Q32-L360)	≥95%
HY-P72400	Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi)	Q92692-2 (Q32-L360)	≥95%
HY-P73307	Nectin-2/CD112 Protein, Human (HEK293)	Q92692-2/NP_002847.1 (Q32-L360)	≥95%
HY-P78372	Nectin-2/CD112 Protein, Human (HEK293, Fc)	Q92692-2 /NP_002847.1(Q32-L360)	≥95%
HY-P78495	Nectin-2/CD112 Protein, Human (HEK293, His-Avi)	Q92692-2 (Q32-L360)	≥95%

NECTIN2 抗体

目录号	产品名	应用	反应物种
HY-P81451	Nectin 2 Antibody (YA1196)	IHC-P	Human

关联疾病

疾病名称

别名

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7	Zlotogora-Ogur Syndrome
CLPED1	Ectodermal Dysplasia, Margarita Island Type
Ed4	Cleft Lip-Palate-Ectodermal Dysplasia Syndrome
Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome	Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate
Ectodermal Dysplasia 4	Ectodermal Dysplasia Margarita Type
Ectodermal Dysplasia, Type 4	Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly
Margarita Type Of Ectodermal Dysplasia	Zlotogora-Zilberman-Tenenbaum Syndrome
Ectd4	Ectodermal Dysplasia 4, Hair/Nail Type
EDMI	Ectodermal Dysplasia Type 4
Margarita Island Ectodermal Dysplasia	Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate
Non-Syndromic Orofacial Cleft 7	OFC7
Non-Syndromic Cleft Lip/Palate 7	Non-Syndromic Cleft Lip With Or Without Cleft Palate 7

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Ovarian Cystic Teratoma

Genital Herpes

Herpes Genitalis	Genital Herpes Simplex
Venereal Herpes	Virus-Genital Herpes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09175	NECTIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NECTIN2	RGD	RGD:1309505
Bos taurus	NECTIN2	VGNC	VGNC:52209
Mus musculus	NECTIN2	MGD	MGI:97822
Macaca mulatta	NECTIN2	VGNC	VGNC:75396
Canis familiaris	NECTIN2	VGNC	VGNC:53741
Macaca fascicularis	NECTIN2	NCBI	NCBI:102137456
Others	NECTIN2	NCBI

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