2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens Receptor Proteins Biotinylated Proteins
  4. Inhibitory Checkpoint Molecules Stimulatory Immune Checkpoint Molecules NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. Immunoglobulin-like Cell Adhesion Molecules
  6. Nectin-2/CD112
  7. Nectin-2/CD112 蛋白, Human (Biotinylated, HEK293, His-Avi)

Nectin-2/CD112 蛋白, Human (Biotinylated, HEK293, His-Avi)

目录号: HY-P72400
产品使用指南

Nectin-2/CD112 蛋白在 T 细胞信号传导中具有双重作用：作为 CD226 的共刺激剂，促进增殖和细胞因子的产生，并作为 PVRIG 的共抑制剂，抑制增殖。它还充当细胞粘附蛋白和某些病毒的受体。Nectin-2/CD112 蛋白, Human (Biotinylated, HEK293, His-Avi) 是重组的 Nectin-2/CD112 蛋白，由 HEK293 表达，带有 C-Avi, C-6*His 标签。Nectin-2/CD112 蛋白, Human (Biotinylated, HEK293, His-Avi) 全长 329 个氨基酸，分子量为 45-60 kDa。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) is 329 a.a., with molecular weight of 45-60 kDa.
研究背景

Nectin-2/CD112 是一种 T 细胞信号传导的多功能调节剂，根据其所结合的受体，具有共刺激剂或共抑制剂的双重作用。与 CD226 结合可促进 T 细胞增殖和细胞因子产生，包括 IL2、IL5、IL10、IL13 和 IFNG 等关键因子。相比之下，与 PVRIG 的相互作用会抑制 T 细胞增殖，并且这些相互作用本质上是竞争性的。此外，如先前的研究所示，Nectin-2/CD112 可能是一种细胞粘附蛋白。此外，在微生物感染的情况下，它充当单纯疱疹病毒 1 (HHV-1) 突变体 Rid1、单纯疱疹病毒 1 (HHV-2) 和伪狂犬病病毒 (PRV) 的受体。
种属

Human
表达系统

HEK293
标签

C-Avi;C-6*His
蛋白编号

Q92692-2 (Q32-L360)
基因 ID
蛋白结构
N-term
CD112 (Q32-L360)
Accession # Q92692-2
6*His-Avi
C-term
同用名
Poliovirus Receptor-Related Protein 2; Herpesvirus Entry Mediator B; HveB; CD112; PVRL2; HVEB; PRR2
氨基酸序列

QDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGP

分子量

45-60 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi)
目录号：
HY-P72400
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z