Nectin-4 蛋白, Human (HEK293, His)

The Nectin-4 Protein IgV domain is pivotal in cell adhesion, participating in trans-homophilic and -heterophilic interactions, notably with NECTIN1. While it doesn't serve as an alpha-herpesvirus entry receptor, it functions as a receptor for measles virus, enabling virus entry into host cells. This dual role underscores the importance of Nectin-4 in cell adhesion and its specific role as a measles virus infection receptor. Nectin-4 Protein, Human (HEK293, His) is the recombinant human-derived Nectin-4 protein, expressed by HEK293 , with C-6*His labeled tag.

Nectin-4 蛋白 IgV 结构域在细胞粘附中发挥着至关重要的作用，参与反同性和反异性相互作用。具体来说，它与 NECTIN1 形成相互作用，有助于细胞粘附过程。然而，它不能作为α-疱疹病毒进入细胞的受体。在微生物感染的情况下，Nectin-4 IgV 结构域充当麻疹病毒的受体，促进病毒进入宿主细胞。这凸显了 Nectin-4 在细胞粘附中的双重作用及其作为麻疹病毒感染特异性受体的重要性。

Immobilized Anti-Human Nectin-4 mAb-mFc at 2 μg/mL (100 μl/well) can bind Human Nectin-4-His .The ED₅₀ of Human Nectin-4-His is 16.29-50 ng/mL.

Human

HEK293

C-6*His

Q96NY8-1 (G32-V351)

81607  [NCBI]

GELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVV

40-47 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4 or 20mM Tris-HCl, 8% Sucrose, 0.05% Tween 80, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.