2. Gene
  3. NECTIN4 - nectin cell adhesion molecule 4 Gene

NECTIN4 - nectin cell adhesion molecule 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：连接蛋白细胞粘附分子 4

种属: Homo sapiens

同用名: LNIR; PRR4; EDSS1; PVRL4; nectin-4

基因 ID: 81607 | 基因类型: protein coding

关于 NECTIN4

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,070,998-161,089,558 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues, 14 paralogues and is associated with 3 phenotypes. Biased expression in skin (RPKM 30.6), esophagus (RPKM 23.7) and 7 other tissues.

功能概要

该基因编码连接蛋白家族的一个成员。编码的蛋白质包含两个免疫球蛋白样 (Ig 样) C2 型结构域和一个 Ig 样 V 型结构域。它通过反式嗜同性和异嗜性相互作用参与细胞粘附。它是一种单程 I 型膜蛋白。可溶性形式是由金属蛋白酶 ADAM17/TACE 在细胞表面进行蛋白水解切割产生的。分泌型存在于乳腺肿瘤细胞系和乳腺肿瘤患者中。该基因的突变是 1 型外胚层发育不良 - 并指综合症的原因，这是一种常染色体隐性遗传病。已发现可变剪接的转录本变体，但尚未确定该变体的全长性质。[RefSeq 提供，2011 年 1 月]

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

NECTIN4 基因产物(1)

mRNA Protein Name
NM_030916.3 NP_112178.2 nectin-4 precursor

NECTIN4 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (36 - 145)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (151 - 232)

ig

ig: Immunoglobulin domain (266 - 317)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
蛋白主名 其他名称

nectin-4

Ig superfamily receptor LNIR

重组 NECTIN4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70616 Nectin-4 Protein, Human (HEK293, His) Q96NY8-1 (G32-V351) ≥95%
HY-P72401 Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi) Q96NY8-1 (G32-V351) ≥95%
HY-P78181 Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi) Q96NY8-1 (G32-L146) ≥95%
HY-P78373 Nectin-4 Protein, Human (HEK293, Fc) Q96NY8-1 (G32-S349) ≥95%
HY-P78374 Nectin-4 Protein, Human (HEK293, His-Avi) Q96NY8-1 (G32-V351) ≥95%
HY-P78375 Nectin-4 Protein, Human (IgV, HEK293, His-Avi) Q96NY8-1 (G32-L146) ≥95%

关联疾病

疾病名称 别名
Ectodermal Dysplasia-Syndactyly Syndrome 1

EDSS1

Ectodermal Dysplasia-Syndactyly Syndrome

Edss

Dysplasia, Ectodermal, Syndactyly Syndrome, Type 1
Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots
Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7

Zlotogora-Ogur Syndrome

CLPED1

Ectodermal Dysplasia, Margarita Island Type

Ed4

Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

Ectodermal Dysplasia 4

Ectodermal Dysplasia Margarita Type

Ectodermal Dysplasia, Type 4

Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

Margarita Type Of Ectodermal Dysplasia

Zlotogora-Zilberman-Tenenbaum Syndrome

Ectd4

Ectodermal Dysplasia 4, Hair/Nail Type

EDMI

Ectodermal Dysplasia Type 4

Margarita Island Ectodermal Dysplasia

Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

Non-Syndromic Orofacial Cleft 7

OFC7

Non-Syndromic Cleft Lip/Palate 7

Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Skin Angiosarcoma

Angiosarcoma Of Skin

Hemangiosarcoma Of The Skin

Haemangiosarcoma Of Skin

Lymphangiosarcoma Of Skin

Cutaneous Angiosarcoma

Malignant Haemangioendothelioma Of Skin
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Testicular Fibroma
Chromosome 2q35 Duplication Syndrome

Syndactyly

Syndactyly Type 1

Sdty1

Zygodactyly

Syndactyly, Type I

Sd1

Syndactyly, Type 1, With Or Without Craniosynostosis

Symphalangism

Non-Syndromic Syndactyly

Symphalangy

Webbing Of Digits

Syndactyly, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99016A Enfortumab vedotin-ejfv Inhibitor 99.28% 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99016 Enfortumab Inhibitor 99.90% 否
Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99016B Enfortumab vedotin-ejfv (solution) Inhibitor 99.78% Phase 3
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-147271 Mal-PEG8-Val-Ala-PAB-Exatecan Inhibitor 99.48% 否
HY-P10524A N188 TFA 99.74% 否
HY-P10524 N188 / 否
HY-RS09177 NECTIN4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NECTIN4 VGNC VGNC:63766
Macaca mulatta NECTIN4 VGNC VGNC:106415
Bos taurus NECTIN4 VGNC VGNC:55633
Canis familiaris NECTIN4 VGNC VGNC:43719
Rattus norvegicus NECTIN4 RGD RGD:1559826
Mus musculus NECTIN4 MGD MGI:1918990
Others NECTIN4 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z