2. 重组蛋白
  3. CAR-T related Proteins Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Immunoglobulin-like Cell Adhesion Molecules
  6. Nectin-4
  7. Nectin-4 蛋白, Human (HEK293, Fc)

Nectin-4 蛋白, Human (HEK293, Fc)

目录号: HY-P78373
产品使用指南

Nectin-4 蛋白 IgV 结构域在细胞粘附中至关重要，参与反同性和反异性相互作用，尤其是与 NECTIN1 的相互作用。虽然它不充当α-疱疹病毒进入受体，但它充当麻疹病毒的受体，使病毒能够进入宿主细胞。这种双重作用强调了 Nectin-4 在细胞粘附中的重要性及其作为麻疹病毒感染受体的特殊作用。Nectin-4 蛋白, Human (HEK293, Fc) 是重组的 Nectin-4 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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描述

The Nectin-4 Protein IgV domain is pivotal in cell adhesion, participating in trans-homophilic and -heterophilic interactions, notably with NECTIN1. While it doesn't serve as an alpha-herpesvirus entry receptor, it functions as a receptor for measles virus, enabling virus entry into host cells. This dual role underscores the importance of Nectin-4 in cell adhesion and its specific role as a measles virus infection receptor. Nectin-4 Protein, Human (HEK293, Fc) is the recombinant human-derived Nectin-4 protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

Nectin-4 蛋白 IgV 结构域在细胞粘附中发挥着至关重要的作用，参与反同性和反异性相互作用。具体来说，它与 NECTIN1 形成相互作用，有助于细胞粘附过程。然而，它不能作为α-疱疹病毒进入细胞的受体。在微生物感染的情况下，Nectin-4 IgV 结构域充当麻疹病毒的受体，促进病毒进入宿主细胞。这凸显了 Nectin-4 在细胞粘附中的双重作用及其作为麻疹病毒感染特异性受体的重要性。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

Q96NY8-1 (G32-S349)
基因 ID
蛋白结构
N-term
Nectin-4 (G32-S349)
Accession # Q96NY8-1
hFc
C-term
同用名
EDSS1; LNIR; Nectin4; PRR4; NECTIN4; PVRL4
分子量

72-74 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Nectin-4 Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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