Neuropilin-1 蛋白, Mouse (HEK293, His)

Neuropilin-1 protein is an important receptor critical for cardiovascular system development, angiogenesis, neuronal circuit formation, and non-nervous system organogenesis.It mediates the chemical pulse activity of signaling proteins, recognizes C-terminal regular motifs on ligands, and promotes cellular internalization and vascular leakage.Neuropilin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Neuropilin-1 蛋白作为一种受体，对于心血管系统的发育、血管生成、特定神经元回路的形成以及神经系统外的器官发生至关重要。作为信号蛋白化学脉冲活性的介体，它识别其配体上的 C 端规则 (CendR) 基序 R/KXXR/K，促进细胞内化和血管渗漏。Neuropilin-1 与信号蛋白 3A (SEMA3A)、PGF 的 PLGF-2 亚型以及 VEGFA 和 VEGFB 的 VEGF165 亚型结合。与 KDR 共表达可增强 VEGF165 与 KDR 的结合并增强趋化性。该蛋白调节 VEGF 诱导的血管生成，并启动对胚胎发育过程中运动神经元轴突引导和细胞体迁移至关重要的信号通路。此外，Neuropilin-1 通过与 ABCB8/MITOSUR 相互作用在调节线粒体铁转运中发挥作用。它与 NRP2 形成同二聚体和异二聚体，结合 PLXNB1，并与线粒体中的 FER、VEGFA 和 ABCB8/MITOSUR 相互作用。

Mouse

HEK293

C-6*His

P97333 (F22-P856)

18186  [NCBI]

FRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDP

100-120 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.