NFKBIE/IKB epsilon 蛋白, Human (His)

NFKBIE/IKB epsilon Protein crucially inhibits NF-kappa-B by forming a cytoplasmic complex, preventing its DNA-binding activity. It targets specific complexes involving p50-p65, p50-c-Rel, and interacts with subunits RELA, REL, NFKB1 (p50), and NFKB2 (p52). NFKBIE/IKB epsilon plays a pivotal role in regulating NF-kappa-B signaling, controlling nuclear translocation and transcriptional activities. NFKBIE/IKB epsilon Protein, Human (His) is the recombinant human-derived NFKBIE/IKB epsilon protein, expressed by E. coli , with N-10*His labeled tag. The total length of NFKBIE/IKB epsilon Protein, Human (His) is 500 a.a., with molecular weight of ~57 kDa.

NFKBIE/IKB epsilon 蛋白通过与 NF-κ-B 形成复合物，从而将其隔离在细胞质中，从而在抑制 NF-κ-B 方面发挥着至关重要的作用。它通过阻止 NF-kappa-B 的 DNA 结合活性发挥其抑制作用，特别针对涉及 p50-p65、p50-c-Rel 的复合物，并与 RELA、REL、NFKB1 (p50) 和NFKB2（第 52 页）。通过这些相互作用，NFKBIE/IKB epsilon 有助于调节 NF-kappa-B 信号传导，在控制其核转位和随后的转录活性中发挥关键作用。

Human

E. coli

N-10*His

O00221 (M1-D500)

4794

MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRGGGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAARRSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLCTD

Approximately 57 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from sterile 50 mM Tris-HCL, 200 mM NaCl, 200 mM arginine, pH 8.0, 10% Glycerol.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.