1. 重组蛋白
  2. Receptor Proteins
  3. Nogo Receptor/NgR 蛋白, Cynomolgus (HEK293, His)

Nogo Receptor/NgR 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P700802
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Nogo 受体/NgR 蛋白作为 RTN4、OMG 和 MAG 的多功能受体发挥作用,扩大了其识别范围,包括唾液酸化神经节苷脂 GT1b 和 GM1、硫酸软骨素蛋白聚糖和肝素。NGFR 辅助受体激活启动 Rho 介导的肌动蛋白细胞骨架重组,导致轴突生长抑制。NgR 在成人中枢神经系统的轴突再生和神经元可塑性中发挥着至关重要的作用,有助于出生后大脑发育、轴突迁移和胼胝体形成。它还可以保护运动神经元免受细胞凋亡,这可能是通过其与 MAG 的相互作用介导的。NgR 与 RTN4 和 LINGO1 合作,调节皮质发育过程中的神经元前体细胞运动。作为同二聚体,它与 OMG、MAG、RTN4、NGFR、LINGO1、KIAA0319L 和 OLFM1 参与复杂的分子网络,揭示了其在细胞过程和神经发育中的多方面作用。Nogo Receptor/NgR 蛋白, Cynomolgus (HEK293, His) 是重组的 Nogo 受体/NgR 蛋白,由 HEK293 表达,带有 C-His 标签。Nogo Receptor/NgR 蛋白, Cynomolgus (HEK293, His) 全长 421 个氨基酸,分子量为 60-73 kDa。

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描述

Nogo Receptor/NgR Protein functions as a versatile receptor for RTN4, OMG, and MAG, broadening its recognition to include sialylated gangliosides GT1b and GM1, chondroitin sulfate proteoglycans, and heparin. NGFR coreceptor activation initiates Rho-mediated actin cytoskeleton reorganization, leading to axonal growth inhibition. NgR plays a crucial role in axon regeneration and neuronal plasticity in the adult central nervous system, contributing to postnatal brain development, axon migration, and corpus callosum formation. It also protects motoneurons against apoptosis, potentially mediated by its interaction with MAG. Collaborating with RTN4 and LINGO1, NgR regulates neuronal precursor cell motility during cortical development. As a homodimer, it engages in a complex molecular network with OMG, MAG, RTN4, NGFR, LINGO1, KIAA0319L, and OLFM1, revealing its multifaceted roles in cellular processes and neural development. Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Nogo Receptor/NgR protein, expressed by HEK293, with C-His labeled tag. The total length of Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His) is 421 a.a., with molecular weight of 60-73 kDa.

研究背景

Nogo 受体/NgR 蛋白作为 RTN4、OMG 和 MAG 的受体,扩展其功能库,包括识别唾液酸化神经节苷脂 GT1b 和 GM1、硫酸软骨素蛋白聚糖和肝素。通过 NGFR 辅助受体激活细胞内信号级联,触发 Rho 介导的下游肌动蛋白细胞骨架重组,导致轴突生长抑制。这种蛋白质可能在调节成人中枢神经系统内的轴突再生和神经元可塑性方面发挥着至关重要的作用,有助于出生后大脑发育、轴突迁移和胼胝体形成。Nogo 受体/NgR 还对运动神经元表现出抗凋亡的保护作用,这可能是通过其与 MAG 的相互作用介导的。它与 RTN4 和 LINGO1 合作,参与皮质发育过程中神经元前体细胞运动的调节。此外,与其他家族成员类似,它与大脑发育过程中树突棘和突触数量的控制有关。作为同二聚体,Nogo 受体/NgR 参与与各种伙伴(包括 OMG、MAG、RTN4、NGFR、LINGO1、KIAA0319L 和 OLFM1)分子相互作用的复杂网络,进一步阐明其在细胞过程和神经发育中的多方面作用。

种属

Cynomolgus

表达系统

HEK293

标签

C-His

蛋白编号

Q9N0E3 (C27-S447)

基因 ID
蛋白结构
N-term
NgR (C27-S447)
Accession # Q9N0E3
His
C-term
同用名
Nogo receptor; RTN4R; NOGOR; NgR1; Nogo-66 receptor; NGR
分子量

60-73 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His)
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HY-P700802
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