NT-4 蛋白, Mouse

NT-4 Protein, Mouse is a member of neurotrophins family, binding with two distinct receptors: TrkB, high affinity receptor and p75 low-affinity neurotrophin receptor (p75NTR).

Neurotropin-4 (NT-4) 是经过充分研究的神经营养蛋白家族的一员，它通过参与神经元过程的生长、突触发育和可塑性、神经元存活、分化以及髓鞘形成来调节神经元网络的发育。Neurotropin-4 与两种不同的受体结合：TrkB、高亲和力受体和 p75 低亲和力神经营养素受体 (p75NTR)^[1]。

The ED₅₀ is <1 μg/mL as measured by C6 cells, corresponding to a specific activity of >1.0 × 10³ units/mg.

Mouse

E. coli

Tag Free

Q80VU4 (G80-A209)

78405  [NCBI]

MGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKAESAGEGGPGVGGGGCRGVDRRHWLSECKAKQSYVRALTADSQGRVGWRWIRIDTACVCTLLSRTGRA

Approximately 14.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against 50 mM acetic acid.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O or 50 mM acetic acid. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. D'Angelo L, et al. Neurotrophin-4 in the brain of adult Nothobranchius furzeri. Ann Anat. 2016 Sep;207:47-54.  [Content Brief]