OBCAM/OPCML 蛋白, Human (HEK293, His)

OBCAM/OPCML Protein uniquely binds opioids, especially in the presence of acidic lipids, indicating a potential role in cellular interactions and signaling related to opioid binding. This dual affinity suggests involvement in cell-contact processes where opioids and acidic lipids are present, highlighting its significance in modulating cellular responses to external stimuli and contributing to opioid-related signaling pathways. OBCAM/OPCML Protein, Human (HEK293, His) is the recombinant human-derived OBCAM/OPCML protein, expressed by HEK293 , with C-His labeled tag.

OBCAM/OPCML 蛋白表现出结合阿片类药物的独特能力，特别是在酸性脂质存在的情况下，表明在与阿片类药物结合相关的细胞相互作用和信号传导中具有潜在作用。这一特征意味着 OBCAM/OPCML 可能参与存在阿片类药物和酸性脂质的细胞接触过程。该蛋白质对阿片类药物和酸性脂质的双重亲和力强调了其在调节细胞对外部刺激的反应中的潜在重要性，并强调了其对阿片类药物相关信号通路的潜在贡献。

Measured by its binding ability in a functional ELISA. Immobilized Human OBCAM at 1 μg/mL (100 μL/well) can bind biotinylated human LSAMP. The ED₅₀ for this effect is 0.9464 μg/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Human OBCAM at 1 μg/mL (100 μL/well) can bind biotinylated human LSAMP. The ED₅₀ for this effect is 0.9464 μg/mL.

Human

HEK293

C-His

Q14982-1/NP_002536.1 (G28-N322)

4978  [NCBI]

GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVN

Approximately 45-60 kDa due to the glycosylation

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.