OPCML - opioid binding protein/cell adhesion molecule like Gene

中文名称：阿片样物质结合蛋白/细胞粘附分子

种属: Homo sapiens

同用名: OPCM; OBCAM; IGLON1

关于 OPCML

功能概要

该基因编码免疫球蛋白超家族中 IgLON 亚家族的成员。编码的前蛋白经过蛋白水解处理以生成成熟蛋白。这种蛋白质位于质膜中，可能在阿片受体功能中起辅助作用。该基因在大鼠和牛中具有直系同源物。大鼠基因编码的阿片样物质结合细胞粘附分子在酸性脂质存在的情况下结合阿片样物质生物碱，表现出对 mu 配体的选择性，并充当 GPI 锚定蛋白。由于编码的蛋白质在进化过程中在物种中高度保守，因此它可能在哺乳动物系统中具有基础性作用。可变剪接导致多个转录本变体，其中至少一个编码一种经过蛋白水解处理的亚型。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in Opioid Receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid Alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]